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Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?

Atopic dermatitis (AD) is a pathological skin condition with complex aetiological mechanisms that are difficult to fully understand. Scientific evidence suggests that of all the causes, the impairment of the skin barrier and cutaneous dysbiosis together with immunological dysfunction can be consider...

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Autores principales: Magnifico, Irene, Petronio Petronio, Giulio, Venditti, Noemi, Cutuli, Marco Alfio, Pietrangelo, Laura, Vergalito, Franca, Mangano, Katia, Zella, Davide, Di Marco, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700401/
https://www.ncbi.nlm.nih.gov/pubmed/33266440
http://dx.doi.org/10.3390/ph13110411
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author Magnifico, Irene
Petronio Petronio, Giulio
Venditti, Noemi
Cutuli, Marco Alfio
Pietrangelo, Laura
Vergalito, Franca
Mangano, Katia
Zella, Davide
Di Marco, Roberto
author_facet Magnifico, Irene
Petronio Petronio, Giulio
Venditti, Noemi
Cutuli, Marco Alfio
Pietrangelo, Laura
Vergalito, Franca
Mangano, Katia
Zella, Davide
Di Marco, Roberto
author_sort Magnifico, Irene
collection PubMed
description Atopic dermatitis (AD) is a pathological skin condition with complex aetiological mechanisms that are difficult to fully understand. Scientific evidence suggests that of all the causes, the impairment of the skin barrier and cutaneous dysbiosis together with immunological dysfunction can be considered as the two main factors involved in this pathological skin condition. The loss of the skin barrier function is often linked to dysbiosis and immunological dysfunction, with an imbalance in the ratio between the pathogen Staphylococcus aureus and/or other microorganisms residing in the skin. The bibliographic research was conducted on PubMed, using the following keywords: ‘atopic dermatitis’, ‘bacterial therapy’, ‘drug delivery system’ and ‘alternative therapy’. The main studies concerning microbial therapy, such as the use of bacteria and/or part thereof with microbiota transplantation, and drug delivery systems to recover skin barrier function have been summarized. The studies examined show great potential in the development of effective therapeutic strategies for AD and AD-like symptoms. Despite this promise, however, future investigative efforts should focus both on the replication of some of these studies on a larger scale, with clinical and demographic characteristics that reflect the general AD population, and on the process of standardisation, in order to produce reliable data.
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spelling pubmed-77004012020-11-30 Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy? Magnifico, Irene Petronio Petronio, Giulio Venditti, Noemi Cutuli, Marco Alfio Pietrangelo, Laura Vergalito, Franca Mangano, Katia Zella, Davide Di Marco, Roberto Pharmaceuticals (Basel) Review Atopic dermatitis (AD) is a pathological skin condition with complex aetiological mechanisms that are difficult to fully understand. Scientific evidence suggests that of all the causes, the impairment of the skin barrier and cutaneous dysbiosis together with immunological dysfunction can be considered as the two main factors involved in this pathological skin condition. The loss of the skin barrier function is often linked to dysbiosis and immunological dysfunction, with an imbalance in the ratio between the pathogen Staphylococcus aureus and/or other microorganisms residing in the skin. The bibliographic research was conducted on PubMed, using the following keywords: ‘atopic dermatitis’, ‘bacterial therapy’, ‘drug delivery system’ and ‘alternative therapy’. The main studies concerning microbial therapy, such as the use of bacteria and/or part thereof with microbiota transplantation, and drug delivery systems to recover skin barrier function have been summarized. The studies examined show great potential in the development of effective therapeutic strategies for AD and AD-like symptoms. Despite this promise, however, future investigative efforts should focus both on the replication of some of these studies on a larger scale, with clinical and demographic characteristics that reflect the general AD population, and on the process of standardisation, in order to produce reliable data. MDPI 2020-11-22 /pmc/articles/PMC7700401/ /pubmed/33266440 http://dx.doi.org/10.3390/ph13110411 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Magnifico, Irene
Petronio Petronio, Giulio
Venditti, Noemi
Cutuli, Marco Alfio
Pietrangelo, Laura
Vergalito, Franca
Mangano, Katia
Zella, Davide
Di Marco, Roberto
Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?
title Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?
title_full Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?
title_fullStr Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?
title_full_unstemmed Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?
title_short Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?
title_sort atopic dermatitis as a multifactorial skin disorder. can the analysis of pathophysiological targets represent the winning therapeutic strategy?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700401/
https://www.ncbi.nlm.nih.gov/pubmed/33266440
http://dx.doi.org/10.3390/ph13110411
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