Cargando…

Combination Therapy to Treat Fungal Biofilm-Based Infections

An increasing number of people is affected by fungal biofilm-based infections, which are resistant to the majority of currently-used antifungal drugs. Such infections are often caused by species from the genera Candida, Aspergillus or Cryptococcus. Only a few antifungal drugs, including echinocandin...

Descripción completa

Detalles Bibliográficos
Autores principales: Tits, Jana, Cammue, Bruno P. A., Thevissen, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700406/
https://www.ncbi.nlm.nih.gov/pubmed/33238622
http://dx.doi.org/10.3390/ijms21228873
_version_ 1783616272642080768
author Tits, Jana
Cammue, Bruno P. A.
Thevissen, Karin
author_facet Tits, Jana
Cammue, Bruno P. A.
Thevissen, Karin
author_sort Tits, Jana
collection PubMed
description An increasing number of people is affected by fungal biofilm-based infections, which are resistant to the majority of currently-used antifungal drugs. Such infections are often caused by species from the genera Candida, Aspergillus or Cryptococcus. Only a few antifungal drugs, including echinocandins and liposomal formulations of amphotericin B, are available to treat such biofilm-based fungal infections. This review discusses combination therapy as a novel antibiofilm strategy. More specifically, in vitro methods to discover new antibiofilm combinations will be discussed. Furthermore, an overview of the main modes of action of promising antibiofilm combination treatments will be provided as this knowledge may facilitate the optimization of existing antibiofilm combinations or the development of new ones with a similar mode of action.
format Online
Article
Text
id pubmed-7700406
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77004062020-11-30 Combination Therapy to Treat Fungal Biofilm-Based Infections Tits, Jana Cammue, Bruno P. A. Thevissen, Karin Int J Mol Sci Review An increasing number of people is affected by fungal biofilm-based infections, which are resistant to the majority of currently-used antifungal drugs. Such infections are often caused by species from the genera Candida, Aspergillus or Cryptococcus. Only a few antifungal drugs, including echinocandins and liposomal formulations of amphotericin B, are available to treat such biofilm-based fungal infections. This review discusses combination therapy as a novel antibiofilm strategy. More specifically, in vitro methods to discover new antibiofilm combinations will be discussed. Furthermore, an overview of the main modes of action of promising antibiofilm combination treatments will be provided as this knowledge may facilitate the optimization of existing antibiofilm combinations or the development of new ones with a similar mode of action. MDPI 2020-11-23 /pmc/articles/PMC7700406/ /pubmed/33238622 http://dx.doi.org/10.3390/ijms21228873 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tits, Jana
Cammue, Bruno P. A.
Thevissen, Karin
Combination Therapy to Treat Fungal Biofilm-Based Infections
title Combination Therapy to Treat Fungal Biofilm-Based Infections
title_full Combination Therapy to Treat Fungal Biofilm-Based Infections
title_fullStr Combination Therapy to Treat Fungal Biofilm-Based Infections
title_full_unstemmed Combination Therapy to Treat Fungal Biofilm-Based Infections
title_short Combination Therapy to Treat Fungal Biofilm-Based Infections
title_sort combination therapy to treat fungal biofilm-based infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700406/
https://www.ncbi.nlm.nih.gov/pubmed/33238622
http://dx.doi.org/10.3390/ijms21228873
work_keys_str_mv AT titsjana combinationtherapytotreatfungalbiofilmbasedinfections
AT cammuebrunopa combinationtherapytotreatfungalbiofilmbasedinfections
AT thevissenkarin combinationtherapytotreatfungalbiofilmbasedinfections