Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension

The autonomic nervous system (ANS) and renin-angiotensin-aldosterone system (RAAS) are involved in many cardiovascular disorders, including pulmonary hypertension (PH). The current review focuses on the role of the ANS and RAAS activation in PH and updated evidence of potential therapies targeting b...

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Autores principales: García-Lunar, Inés, Pereda, Daniel, Ibanez, Borja, García-Álvarez, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700466/
https://www.ncbi.nlm.nih.gov/pubmed/33266371
http://dx.doi.org/10.3390/cells9112521
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author García-Lunar, Inés
Pereda, Daniel
Ibanez, Borja
García-Álvarez, Ana
author_facet García-Lunar, Inés
Pereda, Daniel
Ibanez, Borja
García-Álvarez, Ana
author_sort García-Lunar, Inés
collection PubMed
description The autonomic nervous system (ANS) and renin-angiotensin-aldosterone system (RAAS) are involved in many cardiovascular disorders, including pulmonary hypertension (PH). The current review focuses on the role of the ANS and RAAS activation in PH and updated evidence of potential therapies targeting both systems in this condition, particularly in Groups 1 and 2. State of the art knowledge in preclinical and clinical use of pharmacologic drugs (beta-blockers, beta-three adrenoceptor agonists, or renin-angiotensin-aldosterone signaling drugs) and invasive procedures, such as pulmonary artery denervation, is provided.
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spelling pubmed-77004662020-11-30 Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension García-Lunar, Inés Pereda, Daniel Ibanez, Borja García-Álvarez, Ana Cells Review The autonomic nervous system (ANS) and renin-angiotensin-aldosterone system (RAAS) are involved in many cardiovascular disorders, including pulmonary hypertension (PH). The current review focuses on the role of the ANS and RAAS activation in PH and updated evidence of potential therapies targeting both systems in this condition, particularly in Groups 1 and 2. State of the art knowledge in preclinical and clinical use of pharmacologic drugs (beta-blockers, beta-three adrenoceptor agonists, or renin-angiotensin-aldosterone signaling drugs) and invasive procedures, such as pulmonary artery denervation, is provided. MDPI 2020-11-22 /pmc/articles/PMC7700466/ /pubmed/33266371 http://dx.doi.org/10.3390/cells9112521 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
García-Lunar, Inés
Pereda, Daniel
Ibanez, Borja
García-Álvarez, Ana
Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension
title Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension
title_full Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension
title_fullStr Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension
title_full_unstemmed Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension
title_short Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension
title_sort neurohormonal modulation as a therapeutic target in pulmonary hypertension
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700466/
https://www.ncbi.nlm.nih.gov/pubmed/33266371
http://dx.doi.org/10.3390/cells9112521
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