Oxoglutarate Carrier Inhibition Reduced Melanoma Growth and Invasion by Reducing ATP Production

Recent findings indicate that (a) mitochondria in proliferating cancer cells are functional, (b) cancer cells use more oxygen than normal cells for oxidative phosphorylation, and (c) cancer cells critically rely on cytosolic NADH transported into mitochondria via the malate-aspartate shuttle (MAS) f...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jae-Seon, Choi, Jiwon, Lee, Seon-Hyeong, Kang, Joon Hee, Ha, Ji Sun, Kim, Hee Yeon, Jang, Hyonchol, Yook, Jong In, Kim, Soo-Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700517/
https://www.ncbi.nlm.nih.gov/pubmed/33238375
http://dx.doi.org/10.3390/pharmaceutics12111128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700517/
https://www.ncbi.nlm.nih.gov/pubmed/33238375
http://dx.doi.org/10.3390/pharmaceutics12111128

Ejemplares similares