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Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk
Psychosocial stress increases cardiovascular risk, which coincides with enhanced oxidative DNA damage. Increased sympathetic tone-related catecholamine release causes oxidative stress, which contributes to catecholamine-related cardiotoxicity. Therefore, we tested the hypothesis whether acute psycho...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700520/ https://www.ncbi.nlm.nih.gov/pubmed/33238572 http://dx.doi.org/10.3390/jcm9113783 |
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author | Waller, Christiane Rhee, Dae-Sup Gröger, Michael Rappel, Manuela Maier, Tanja Müller, Markus Rottler, Edit Nerz, Katharina Nerz, Christopher Brill, Sebastian Becker, Horst-Peter Radermacher, Peter |
author_facet | Waller, Christiane Rhee, Dae-Sup Gröger, Michael Rappel, Manuela Maier, Tanja Müller, Markus Rottler, Edit Nerz, Katharina Nerz, Christopher Brill, Sebastian Becker, Horst-Peter Radermacher, Peter |
author_sort | Waller, Christiane |
collection | PubMed |
description | Psychosocial stress increases cardiovascular risk, which coincides with enhanced oxidative DNA damage. Increased sympathetic tone-related catecholamine release causes oxidative stress, which contributes to catecholamine-related cardiotoxicity. Therefore, we tested the hypothesis whether acute psychosocial stress induces oxidative DNA damage, its degree being related to the cardiovascular risk profile and depending on the sympathetic stress response. After assessment of the prospective cardiovascular Münster score (PROCAM) to determine the risk of acute myocardial infarction, 83 male and 12 female healthy volunteers underwent the Trier social stress test for groups (TSST-G). Heart rate variability was quantified by measuring the standard deviation (SDNN) and root mean square of successive differences (RMSSD) between normal-to-normal inter-beat intervals. Salivary α-amylase (sAA) activity was assessed as a surrogate for noradrenaline plasma concentrations. Oxidative DNA damage was determined using whole-blood single-cell gel electrophoresis (“tail moment” in the “comet assay”). A total of 33 subjects presented with a prospective risk of myocardial infarction (risk+) vs. 59 subjects without risk (risk-). The TSST-G stress significantly increased blood pressure, heart rate, and sAA in both groups, while oxidative DNA damage was only increased in the risk+ group. Immediately after the TSST-G, the “tail moment” showed significant inverse linear relations with both SDNN and RMSSD. Acute psychosocial stress may cause oxidative DNA damage, the degree of which is directly related to the individual cardiovascular risk profile and depends on the stress-induced increase in the sympathetic tone. |
format | Online Article Text |
id | pubmed-7700520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77005202020-11-30 Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk Waller, Christiane Rhee, Dae-Sup Gröger, Michael Rappel, Manuela Maier, Tanja Müller, Markus Rottler, Edit Nerz, Katharina Nerz, Christopher Brill, Sebastian Becker, Horst-Peter Radermacher, Peter J Clin Med Article Psychosocial stress increases cardiovascular risk, which coincides with enhanced oxidative DNA damage. Increased sympathetic tone-related catecholamine release causes oxidative stress, which contributes to catecholamine-related cardiotoxicity. Therefore, we tested the hypothesis whether acute psychosocial stress induces oxidative DNA damage, its degree being related to the cardiovascular risk profile and depending on the sympathetic stress response. After assessment of the prospective cardiovascular Münster score (PROCAM) to determine the risk of acute myocardial infarction, 83 male and 12 female healthy volunteers underwent the Trier social stress test for groups (TSST-G). Heart rate variability was quantified by measuring the standard deviation (SDNN) and root mean square of successive differences (RMSSD) between normal-to-normal inter-beat intervals. Salivary α-amylase (sAA) activity was assessed as a surrogate for noradrenaline plasma concentrations. Oxidative DNA damage was determined using whole-blood single-cell gel electrophoresis (“tail moment” in the “comet assay”). A total of 33 subjects presented with a prospective risk of myocardial infarction (risk+) vs. 59 subjects without risk (risk-). The TSST-G stress significantly increased blood pressure, heart rate, and sAA in both groups, while oxidative DNA damage was only increased in the risk+ group. Immediately after the TSST-G, the “tail moment” showed significant inverse linear relations with both SDNN and RMSSD. Acute psychosocial stress may cause oxidative DNA damage, the degree of which is directly related to the individual cardiovascular risk profile and depends on the stress-induced increase in the sympathetic tone. MDPI 2020-11-23 /pmc/articles/PMC7700520/ /pubmed/33238572 http://dx.doi.org/10.3390/jcm9113783 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Waller, Christiane Rhee, Dae-Sup Gröger, Michael Rappel, Manuela Maier, Tanja Müller, Markus Rottler, Edit Nerz, Katharina Nerz, Christopher Brill, Sebastian Becker, Horst-Peter Radermacher, Peter Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk |
title | Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk |
title_full | Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk |
title_fullStr | Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk |
title_full_unstemmed | Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk |
title_short | Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk |
title_sort | social stress-induced oxidative dna damage is related to prospective cardiovascular risk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700520/ https://www.ncbi.nlm.nih.gov/pubmed/33238572 http://dx.doi.org/10.3390/jcm9113783 |
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