Cargando…

A Combined Systemic Strategy for Overcoming Cisplatin Resistance in Head and Neck Cancer: From Target Identification to Drug Discovery

SIMPLE SUMMARY: The efficiency of cisplatin is limited by drug resistance in head–neck cancer (HNC) patients. In this study, we established a cisplatin resistance (CR) cell model, generated CR related transcriptome profiling, and combined application of bioinformatics methodology to discover a possi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yin-Ju, You, Guo-Rung, Lai, Meng-Yu, Lu, Long-Sheng, Chen, Chang-Yu, Ting, Lai-Lei, Lee, Hsin-Lun, Kanno, Yuzuka, Chiou, Jeng-Fong, Cheng, Ann-Joy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700594/ https://www.ncbi.nlm.nih.gov/pubmed/33238517 http://dx.doi.org/10.3390/cancers12113482

Ejemplares similares

Molecular Mechanisms of Chemotherapy Resistance in Head and Neck Cancers
por: Kanno, Yuzuka, et al.
Publicado: (2021)

Prognostic signature associated with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses
por: You, Guo-Rung, et al.
Publicado: (2019)

Cisplatin-induced regulation of signal transduction pathways and transcription factors in p53-mutated subclone variants of hepatoma cells: Potential application for therapeutic targeting
por: Kuo, Jinn-Rung, et al.
Publicado: (2016)

Ex Vivo Expanded Circulating Tumor Cells for Clinical Anti-Cancer Drug Prediction in Patients with Head and Neck Cancer
por: Lin, Kuan-Chou, et al.
Publicado: (2021)

MiR-520b as a novel molecular target for suppressing stemness phenotype of head-neck cancer by inhibiting CD44
por: Lu, Ya-Ching, et al.
Publicado: (2017)

The Vitamin D Receptor–BIM Axis Overcomes Cisplatin Resistance in Head and Neck Cancer
por: Khamis, Aya, et al.
Publicado: (2022)

Molecular Signature of Long Non-Coding RNA Associated with Areca Nut-Induced Head and Neck Cancer
por: Huang, Hung-Han, et al.
Publicado: (2023)

Molecular Interplays Between Cell Invasion and Radioresistance That Lead to Poor Prognosis in Head-Neck Cancer
por: You, Guo-Rung, et al.
Publicado: (2021)

The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness
por: Chen, Hsin-Ying, et al.
Publicado: (2018)

Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin
por: Hsieh, Chen-Hsi, et al.
Publicado: (2013)

Multifaceted and Intricate Oncogenic Mechanisms of NDRG1 in Head and Neck Cancer Depend on Its C-Terminal 3R-Motif
por: You, Guo-Rung, et al.
Publicado: (2022)

Cisplatin-Based Chemotherapy versus Cetuximab in Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer Treatment
por: Hu, Ming-Hung, et al.
Publicado: (2014)

GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway
por: Li, Yan-Liang, et al.
Publicado: (2016)

7‐Epitaxol induces apoptosis in cisplatin‐resistant head and neck squamous cell carcinoma via suppression of AKT and MAPK signalling
por: Yang, Hui‐Ju, et al.
Publicado: (2022)

Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells
por: Chen, Ying-Hui, et al.
Publicado: (2013)

Tumor Suppressor miRNA-503 Inhibits Cell Invasion in Head and Neck Cancer through the Wnt Signaling Pathway via the WNT3A/MMP Molecular Axis
por: Tang, Shang-Ju, et al.
Publicado: (2022)

Systemic Investigation Identifying Salivary miR-196b as a Promising Biomarker for Early Detection of Head-Neck Cancer and Oral Precancer Lesions
por: Cheng, Ann-Joy, et al.
Publicado: (2021)

Chemoradiotherapy With Generic Cisplatin Formulations for Head and Neck Cancers
por: Shimada, Rie, et al.
Publicado: (2018)

Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer
por: Lu, Hsueh-Ju, et al.
Publicado: (2015)

Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress
por: Yu, Wangjie, et al.
Publicado: (2020)

Systematic Analysis and Identification of Dysregulated Panel lncRNAs Contributing to Poor Prognosis in Head-Neck Cancer
por: Tang, Shang-Ju, et al.
Publicado: (2021)

Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis
por: Lee, Jaewang, et al.
Publicado: (2020)

Dementia Risk in Irradiated Patients With Head and Neck Cancer
por: Chen, Jin-Hua, et al.
Publicado: (2015)

Chemoradiation with Cisplatin vs. Carboplatin for Squamous Cell Carcinoma of the Head and Neck (SCCHN)
por: Rades, Dirk, et al.
Publicado: (2023)

Comparison of vinorelbine with cisplatin in concomitant chemoradiotherapy in head and neck carcinoma
por: Devleena,, et al.
Publicado: (2010)

Prognostic Factors for the Therapeutic Performance of Cisplatin in Head and Neck Malignancies
por: Jungbauer, Frederic, et al.
Publicado: (2022)

MEK blockade overcomes the limited activity of palbociclib in head and neck cancer
por: Fang, Zhenghuan, et al.
Publicado: (2020)

Precision Medicine Approaches to Overcome Resistance to Therapy in Head and Neck Cancers
por: Ortiz-Cuaran, Sandra, et al.
Publicado: (2021)

The Role of Immunotherapy to Overcome Resistance in Viral-Associated Head and Neck Cancer
por: Pharaon, Rebecca R., et al.
Publicado: (2021)

NM23-H1 expression of head and neck squamous cell carcinoma in association with the response to cisplatin treatment
por: Wang, Yi-Fen, et al.
Publicado: (2014)

Cisplatin and paclitaxel co-delivered by folate-decorated lipid carriers for the treatment of head and neck cancer
por: Yang, Jiying, et al.
Publicado: (2017)

Primary treatment of painful bone metastases using magnetic resonance guided focused ultrasound – initial clinical experience in Taiwan
por: Lee, Hsin-Lun, et al.
Publicado: (2015)

Cisplatin for cancer therapy and overcoming chemoresistance
por: Ranasinghe, Ranmali, et al.
Publicado: (2022)

Decitabine Rescues Cisplatin Resistance in Head and Neck Squamous Cell Carcinoma
por: Viet, Chi T., et al.
Publicado: (2014)

Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells
por: Möckelmann, Nikolaus, et al.
Publicado: (2016)

Multi-kinase inhibitors and cisplatin for head and neck cancer treatment in vitro
por: Brands, Roman C., et al.
Publicado: (2019)

Identification of hub genes involved in cisplatin resistance in head and neck cancer
por: Chaudhary, Raushan Kumar, et al.
Publicado: (2023)

MicroRNAs as the pivotal regulators of cisplatin resistance in head and neck cancers
por: Tolue Ghasaban, Faezeh, et al.
Publicado: (2023)

Overcoming Resistance to Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinomas
por: dos Santos, Lucas V., et al.
Publicado: (2021)

Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review
por: Hui, Caressa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rk70s2f17buiq0qu908dmg2gj7