Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair

Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is well documented for a broad spectrum of human malignancies supporting their growth and progression. Accumulating evidence has also implicated AKT as a potent modulator of anti-cancer therapies via regulation of DNA damage respons...

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Detalles Bibliográficos
Autores principales: Boichuk, Sergei, Bikinieva, Firuza, Nurgatina, Ilmira, Dunaev, Pavel, Valeeva, Elena, Aukhadieva, Aida, Sabirov, Alexey, Galembikova, Aigul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700672/
https://www.ncbi.nlm.nih.gov/pubmed/33266502
http://dx.doi.org/10.3390/ijms21228842

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