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Evolutionary dynamics and geographic dispersal of beta coronaviruses in African bats

Bats have been shown to serve as reservoir host of various viral agents including coronaviruses. They have also been associated with the novel coronavirus SARS-CoV-2. This has made them an all important agent for CoV evolution and transmission. Our objective in this study was to investigate the disp...

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Autores principales: Motayo, Babatunde O., Oluwasemowo, Olukunle Oluwapamilerin, Akinduti, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700737/
https://www.ncbi.nlm.nih.gov/pubmed/33304657
http://dx.doi.org/10.7717/peerj.10434
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author Motayo, Babatunde O.
Oluwasemowo, Olukunle Oluwapamilerin
Akinduti, Paul A.
author_facet Motayo, Babatunde O.
Oluwasemowo, Olukunle Oluwapamilerin
Akinduti, Paul A.
author_sort Motayo, Babatunde O.
collection PubMed
description Bats have been shown to serve as reservoir host of various viral agents including coronaviruses. They have also been associated with the novel coronavirus SARS-CoV-2. This has made them an all important agent for CoV evolution and transmission. Our objective in this study was to investigate the dispersal, phylogenomics and evolution of betacoronavirus (βCoV) among African bats. We retrieved sequence data from established databases such as GenBank and Virus Pathogen Resource, covering the partial RNA dependent RNA polymerase (RdRP) gene of bat coronaviruses from eight African, three Asian, five European, two South American countries and Australia. We analyzed for phylogeographic information relating to genetic diversity and evolutionary dynamics. Our study revealed that majority of the African strains fell within Norbecovirus subgenera, with an evolutionary rate of 1.301 × 10(−3), HPD (1.064 × 10(−3)–1.434 × 10(−3)) subs/site/year. The African strains diversified into three main subgenera, Norbecovirus, Hibecovirus and Merbecovirus. The time to most common recent ancestor for Norbecovirus strains was 1973, and 2007, for the African Merbecovirus strains. There was evidence of inter species transmission of Norbecovirus among bats in Cameroun and DRC. Phlylogeography showed that there were inter-continental spread of Bt-CoV from Europe, China and Hong Kong into Central and Southern Africa, highlighting the possibility of long distance transmission. Our study has elucidated the possible evolutionary origins of βCoV among African bats; we therefore advocate for broader studies of whole genome sequences of BtCoV to further understand the drivers for their emergence and zoonotic spillovers into human population.
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spelling pubmed-77007372020-12-09 Evolutionary dynamics and geographic dispersal of beta coronaviruses in African bats Motayo, Babatunde O. Oluwasemowo, Olukunle Oluwapamilerin Akinduti, Paul A. PeerJ Evolutionary Studies Bats have been shown to serve as reservoir host of various viral agents including coronaviruses. They have also been associated with the novel coronavirus SARS-CoV-2. This has made them an all important agent for CoV evolution and transmission. Our objective in this study was to investigate the dispersal, phylogenomics and evolution of betacoronavirus (βCoV) among African bats. We retrieved sequence data from established databases such as GenBank and Virus Pathogen Resource, covering the partial RNA dependent RNA polymerase (RdRP) gene of bat coronaviruses from eight African, three Asian, five European, two South American countries and Australia. We analyzed for phylogeographic information relating to genetic diversity and evolutionary dynamics. Our study revealed that majority of the African strains fell within Norbecovirus subgenera, with an evolutionary rate of 1.301 × 10(−3), HPD (1.064 × 10(−3)–1.434 × 10(−3)) subs/site/year. The African strains diversified into three main subgenera, Norbecovirus, Hibecovirus and Merbecovirus. The time to most common recent ancestor for Norbecovirus strains was 1973, and 2007, for the African Merbecovirus strains. There was evidence of inter species transmission of Norbecovirus among bats in Cameroun and DRC. Phlylogeography showed that there were inter-continental spread of Bt-CoV from Europe, China and Hong Kong into Central and Southern Africa, highlighting the possibility of long distance transmission. Our study has elucidated the possible evolutionary origins of βCoV among African bats; we therefore advocate for broader studies of whole genome sequences of BtCoV to further understand the drivers for their emergence and zoonotic spillovers into human population. PeerJ Inc. 2020-11-26 /pmc/articles/PMC7700737/ /pubmed/33304657 http://dx.doi.org/10.7717/peerj.10434 Text en © 2020 Motayo et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Evolutionary Studies
Motayo, Babatunde O.
Oluwasemowo, Olukunle Oluwapamilerin
Akinduti, Paul A.
Evolutionary dynamics and geographic dispersal of beta coronaviruses in African bats
title Evolutionary dynamics and geographic dispersal of beta coronaviruses in African bats
title_full Evolutionary dynamics and geographic dispersal of beta coronaviruses in African bats
title_fullStr Evolutionary dynamics and geographic dispersal of beta coronaviruses in African bats
title_full_unstemmed Evolutionary dynamics and geographic dispersal of beta coronaviruses in African bats
title_short Evolutionary dynamics and geographic dispersal of beta coronaviruses in African bats
title_sort evolutionary dynamics and geographic dispersal of beta coronaviruses in african bats
topic Evolutionary Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700737/
https://www.ncbi.nlm.nih.gov/pubmed/33304657
http://dx.doi.org/10.7717/peerj.10434
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