Potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals

HIV-positive TB co-infected patients are at increased risk of multidrug-resistant (MDR)-TB compared to HIV-negative patients. Co-treatment of MDR-TB and HIV is common particularly in Sub-Saharan Africa where the co-morbidity is endemic. We discuss potential cellular metabolic pathway–mediated drug–d...

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Detalles Bibliográficos
Autores principales: Mukonzo, Jackson, Aklillu, Eleni, Marconi, Vincent, Schinazi, Raymond F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700887/
https://www.ncbi.nlm.nih.gov/pubmed/30991140
http://dx.doi.org/10.1016/j.ijid.2019.04.009
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author Mukonzo, Jackson
Aklillu, Eleni
Marconi, Vincent
Schinazi, Raymond F.
author_facet Mukonzo, Jackson
Aklillu, Eleni
Marconi, Vincent
Schinazi, Raymond F.
author_sort Mukonzo, Jackson
collection PubMed
description HIV-positive TB co-infected patients are at increased risk of multidrug-resistant (MDR)-TB compared to HIV-negative patients. Co-treatment of MDR-TB and HIV is common particularly in Sub-Saharan Africa where the co-morbidity is endemic. We discuss potential cellular metabolic pathway–mediated drug–drug interactions and the possible effect on HIV treatment outcomes of commonly prescribed antiretroviral therapy.
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spelling pubmed-77008872020-11-30 Potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals Mukonzo, Jackson Aklillu, Eleni Marconi, Vincent Schinazi, Raymond F. Int J Infect Dis Article HIV-positive TB co-infected patients are at increased risk of multidrug-resistant (MDR)-TB compared to HIV-negative patients. Co-treatment of MDR-TB and HIV is common particularly in Sub-Saharan Africa where the co-morbidity is endemic. We discuss potential cellular metabolic pathway–mediated drug–drug interactions and the possible effect on HIV treatment outcomes of commonly prescribed antiretroviral therapy. 2019-04-13 2019-06 /pmc/articles/PMC7700887/ /pubmed/30991140 http://dx.doi.org/10.1016/j.ijid.2019.04.009 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Mukonzo, Jackson
Aklillu, Eleni
Marconi, Vincent
Schinazi, Raymond F.
Potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals
title Potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals
title_full Potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals
title_fullStr Potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals
title_full_unstemmed Potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals
title_short Potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals
title_sort potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: implications for hiv care of mdr-tb co-infected individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700887/
https://www.ncbi.nlm.nih.gov/pubmed/30991140
http://dx.doi.org/10.1016/j.ijid.2019.04.009
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