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Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection

INTRODUCTION: Since studies about clinical status after COVID-19 are scarce, we conducted a cross sectional study with assessment of residual symptoms, lung function and chest CT. MATERIALS AND METHODS: During an outpatient follow-up visit, chest CT, pulmonary function and COVID-19 related symptoms...

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Autores principales: Smet, Jelle, Stylemans, Dimitri, Hanon, Shane, Ilsen, Bart, Verbanck, Sylvia, Vanderhelst, Eef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701883/
https://www.ncbi.nlm.nih.gov/pubmed/33278758
http://dx.doi.org/10.1016/j.rmed.2020.106276
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author Smet, Jelle
Stylemans, Dimitri
Hanon, Shane
Ilsen, Bart
Verbanck, Sylvia
Vanderhelst, Eef
author_facet Smet, Jelle
Stylemans, Dimitri
Hanon, Shane
Ilsen, Bart
Verbanck, Sylvia
Vanderhelst, Eef
author_sort Smet, Jelle
collection PubMed
description INTRODUCTION: Since studies about clinical status after COVID-19 are scarce, we conducted a cross sectional study with assessment of residual symptoms, lung function and chest CT. MATERIALS AND METHODS: During an outpatient follow-up visit, chest CT, pulmonary function and COVID-19 related symptoms were assessed approximately 10 weeks after diagnosis. Demographics, baseline (time of diagnosis) CT score and blood results were collected from patient files. Association between lung function and clinical characteristics (baseline), blood markers (baseline), chest CT (baseline and follow-up) and symptom score (followup) was analysed. Mann-Whitney U tests and Chi squared tests were used for statistical comparison between subgroups with and without restriction. RESULTS AND DISCUSSION: Two hundred-twenty subjects were evaluated at a median follow-up of 74±12 (SD) days. Median symptom and median CT score at follow-up were 1(IQR=0- 2) and 2(IQR=0-6) respectively. Forty-six percent of patients had normal lung function, while TLC and TLCO below the lower limit of normal were observed in 38% and 22% of subjects respectively. This restrictive pulmonary impairment was associated with length of hospital stay (8 vs 6 days; p=0.003), admission to the intensive care unit (27% vs 13%;p=0.009), and invasive mechanical ventilation (10% vs 0.7%;p=0.001), but not with symptom score or CT score at baseline and follow-up. CONCLUSIONS: Fifty-four percent of COVID-19 survivors had abnormal lung function 10 weeks after diagnosis. Restriction was the most prevalent pulmonary function, with the more critically ill patients being more prone to this condition. Yet, restriction could not be linked with abnormal imaging results or residual symptoms.
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spelling pubmed-77018832020-12-01 Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection Smet, Jelle Stylemans, Dimitri Hanon, Shane Ilsen, Bart Verbanck, Sylvia Vanderhelst, Eef Respir Med Short Communication INTRODUCTION: Since studies about clinical status after COVID-19 are scarce, we conducted a cross sectional study with assessment of residual symptoms, lung function and chest CT. MATERIALS AND METHODS: During an outpatient follow-up visit, chest CT, pulmonary function and COVID-19 related symptoms were assessed approximately 10 weeks after diagnosis. Demographics, baseline (time of diagnosis) CT score and blood results were collected from patient files. Association between lung function and clinical characteristics (baseline), blood markers (baseline), chest CT (baseline and follow-up) and symptom score (followup) was analysed. Mann-Whitney U tests and Chi squared tests were used for statistical comparison between subgroups with and without restriction. RESULTS AND DISCUSSION: Two hundred-twenty subjects were evaluated at a median follow-up of 74±12 (SD) days. Median symptom and median CT score at follow-up were 1(IQR=0- 2) and 2(IQR=0-6) respectively. Forty-six percent of patients had normal lung function, while TLC and TLCO below the lower limit of normal were observed in 38% and 22% of subjects respectively. This restrictive pulmonary impairment was associated with length of hospital stay (8 vs 6 days; p=0.003), admission to the intensive care unit (27% vs 13%;p=0.009), and invasive mechanical ventilation (10% vs 0.7%;p=0.001), but not with symptom score or CT score at baseline and follow-up. CONCLUSIONS: Fifty-four percent of COVID-19 survivors had abnormal lung function 10 weeks after diagnosis. Restriction was the most prevalent pulmonary function, with the more critically ill patients being more prone to this condition. Yet, restriction could not be linked with abnormal imaging results or residual symptoms. Elsevier Ltd. 2021-01 2020-11-30 /pmc/articles/PMC7701883/ /pubmed/33278758 http://dx.doi.org/10.1016/j.rmed.2020.106276 Text en © 2020 Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Smet, Jelle
Stylemans, Dimitri
Hanon, Shane
Ilsen, Bart
Verbanck, Sylvia
Vanderhelst, Eef
Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection
title Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection
title_full Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection
title_fullStr Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection
title_full_unstemmed Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection
title_short Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection
title_sort clinical status and lung function 10 weeks after severe sars-cov-2 infection
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701883/
https://www.ncbi.nlm.nih.gov/pubmed/33278758
http://dx.doi.org/10.1016/j.rmed.2020.106276
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