Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors

PINK1 loss-of-function mutations cause early onset Parkinson disease. PINK1-Parkin mediated mitophagy has been well studied, but the relevance of the endogenous process in the brain is debated. Here, the absence of PINK1 in human dopaminergic neurons inhibits ionophore-induced mitophagy and reduces...

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Detalles Bibliográficos
Autores principales: Bus, Christine, Zizmare, Laimdota, Feldkaemper, Marita, Geisler, Sven, Zarani, Maria, Schaedler, Anna, Klose, Franziska, Admard, Jakob, Mageean, Craig J., Arena, Giuseppe, Fallier-Becker, Petra, Ugun-Klusek, Aslihan, Maruszczak, Klaudia K., Kapolou, Konstantina, Schmid, Benjamin, Rapaport, Doron, Ueffing, Marius, Casadei, Nicolas, Krüger, Rejko, Gasser, Thomas, Vogt Weisenhorn, Daniela M., Kahle, Philipp J., Trautwein, Christoph, Gloeckner, Christian J., Fitzgerald, Julia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702004/
https://www.ncbi.nlm.nih.gov/pubmed/33299968
http://dx.doi.org/10.1016/j.isci.2020.101797

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