Friedel–Crafts Type Methylation with Dimethylhalonium Salts

The dimethylchloronium salt [Me(2)Cl][Al(OTeF(5))(4)] is used to methylate electron‐deficient aromatic systems in Friedel–Crafts type reactions as shown by the synthesis of N‐methylated cations, such as [MeNC(5)F(5)](+), [MeNC(5)F(4)I](+), and [MeN(3)C(3)F(3)](+). To gain a better understanding of s...

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Detalles Bibliográficos
Autores principales: Hämmerling, Sebastian, Voßnacker, Patrick, Steinhauer, Simon, Beckers, Helmut, Riedel, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702172/
https://www.ncbi.nlm.nih.gov/pubmed/32277527
http://dx.doi.org/10.1002/chem.202001457
Descripción
Sumario:The dimethylchloronium salt [Me(2)Cl][Al(OTeF(5))(4)] is used to methylate electron‐deficient aromatic systems in Friedel–Crafts type reactions as shown by the synthesis of N‐methylated cations, such as [MeNC(5)F(5)](+), [MeNC(5)F(4)I](+), and [MeN(3)C(3)F(3)](+). To gain a better understanding of such fundamental Friedel–Crafts reactions, the role of the dimethylchloronium cation has been evaluated by quantum‐chemical calculations.

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