Friedel–Crafts Type Methylation with Dimethylhalonium Salts

The dimethylchloronium salt [Me(2)Cl][Al(OTeF(5))(4)] is used to methylate electron‐deficient aromatic systems in Friedel–Crafts type reactions as shown by the synthesis of N‐methylated cations, such as [MeNC(5)F(5)](+), [MeNC(5)F(4)I](+), and [MeN(3)C(3)F(3)](+). To gain a better understanding of s...

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Autores principales: Hämmerling, Sebastian, Voßnacker, Patrick, Steinhauer, Simon, Beckers, Helmut, Riedel, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702172/
https://www.ncbi.nlm.nih.gov/pubmed/32277527
http://dx.doi.org/10.1002/chem.202001457
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author Hämmerling, Sebastian
Voßnacker, Patrick
Steinhauer, Simon
Beckers, Helmut
Riedel, Sebastian
author_facet Hämmerling, Sebastian
Voßnacker, Patrick
Steinhauer, Simon
Beckers, Helmut
Riedel, Sebastian
author_sort Hämmerling, Sebastian
collection PubMed
description The dimethylchloronium salt [Me(2)Cl][Al(OTeF(5))(4)] is used to methylate electron‐deficient aromatic systems in Friedel–Crafts type reactions as shown by the synthesis of N‐methylated cations, such as [MeNC(5)F(5)](+), [MeNC(5)F(4)I](+), and [MeN(3)C(3)F(3)](+). To gain a better understanding of such fundamental Friedel–Crafts reactions, the role of the dimethylchloronium cation has been evaluated by quantum‐chemical calculations.
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spelling pubmed-77021722020-12-14 Friedel–Crafts Type Methylation with Dimethylhalonium Salts Hämmerling, Sebastian Voßnacker, Patrick Steinhauer, Simon Beckers, Helmut Riedel, Sebastian Chemistry Full Papers The dimethylchloronium salt [Me(2)Cl][Al(OTeF(5))(4)] is used to methylate electron‐deficient aromatic systems in Friedel–Crafts type reactions as shown by the synthesis of N‐methylated cations, such as [MeNC(5)F(5)](+), [MeNC(5)F(4)I](+), and [MeN(3)C(3)F(3)](+). To gain a better understanding of such fundamental Friedel–Crafts reactions, the role of the dimethylchloronium cation has been evaluated by quantum‐chemical calculations. John Wiley and Sons Inc. 2020-10-05 2020-11-11 /pmc/articles/PMC7702172/ /pubmed/32277527 http://dx.doi.org/10.1002/chem.202001457 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Hämmerling, Sebastian
Voßnacker, Patrick
Steinhauer, Simon
Beckers, Helmut
Riedel, Sebastian
Friedel–Crafts Type Methylation with Dimethylhalonium Salts
title Friedel–Crafts Type Methylation with Dimethylhalonium Salts
title_full Friedel–Crafts Type Methylation with Dimethylhalonium Salts
title_fullStr Friedel–Crafts Type Methylation with Dimethylhalonium Salts
title_full_unstemmed Friedel–Crafts Type Methylation with Dimethylhalonium Salts
title_short Friedel–Crafts Type Methylation with Dimethylhalonium Salts
title_sort friedel–crafts type methylation with dimethylhalonium salts
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702172/
https://www.ncbi.nlm.nih.gov/pubmed/32277527
http://dx.doi.org/10.1002/chem.202001457
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