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Fragment-derived modulators of an industrial β-glucosidase

A fragment screen of a library of 560 commercially available fragments using a kinetic assay identified a small molecule that increased the activity of the fungal glycoside hydrolase TrBgl2. An analogue by catalogue approach and detailed kinetic analysis identified improved compounds that behaved as...

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Detalles Bibliográficos
Autores principales:	Makraki, Eleni, Darby, John F., Carneiro, Marta G., Firth, James D., Heyam, Alex, Ab, Eiso, O'Brien, Peter, Siegal, Gregg, Hubbard, Roderick E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702302/ https://www.ncbi.nlm.nih.gov/pubmed/33111951 http://dx.doi.org/10.1042/BCJ20200507

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