Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity

Mutations that enhance LRRK2 protein kinase activity cause inherited Parkinson's disease. LRRK2 phosphorylates a group of Rab GTPase proteins, including Rab10 and Rab12, within the effector-binding switch-II motif. Previous work has indicated that the PARK16 locus, which harbors the gene encodi...

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Detalles Bibliográficos
Autores principales: Kalogeropulou, Alexia F., Freemantle, Jordana B., Lis, Pawel, Vides, Edmundo G., Polinski, Nicole K., Alessi, Dario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702304/
https://www.ncbi.nlm.nih.gov/pubmed/33135724
http://dx.doi.org/10.1042/BCJ20200458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702304/
https://www.ncbi.nlm.nih.gov/pubmed/33135724
http://dx.doi.org/10.1042/BCJ20200458

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