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Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

BACKGROUND: Tumor angiogenesis is regarded as a rational anti-cancer target. The efficacy and indications of anti-angiogenic therapies in clinical practice, however, are relatively limited. Therefore, there still exists a demand for revealing the distinct characteristics of tumor endothelium that is...

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Detalles Bibliográficos
Autores principales:	Quan, Lili, Ohgaki, Ryuichi, Hara, Saori, Okuda, Suguru, Wei, Ling, Okanishi, Hiroki, Nagamori, Shushi, Endou, Hitoshi, Kanai, Yoshikatsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702703/ https://www.ncbi.nlm.nih.gov/pubmed/33256804 http://dx.doi.org/10.1186/s13046-020-01762-0

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