Human A-to-I RNA editing SNP loci are enriched in GWAS signals for autoimmune diseases and under balancing selection

BACKGROUND: Adenosine-to-inosine (A-to-I) RNA editing plays important roles in diversifying the transcriptome and preventing MDA5 sensing of endogenous dsRNA as nonself. To date, few studies have investigated the population genomic signatures of A-to-I editing due to the lack of editing sites overla...

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Detalles Bibliográficos
Autores principales: Zhang, Hui, Fu, Qiang, Shi, Xinrui, Pan, Ziqing, Yang, Wenbing, Huang, Zichao, Tang, Tian, He, Xionglei, Zhang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702712/
https://www.ncbi.nlm.nih.gov/pubmed/33256812
http://dx.doi.org/10.1186/s13059-020-02205-x

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