Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC–MS/MS

Remdesivir is a prodrug of the nucleotide analogue and used for COVID-19 treatment. However, the bioanalysis of the active metabolites remdesivir nucleotide triphosphate (RTP) and its precursor remdesivir nucleotide monophosphate (RMP) is very challenging. Herein, we established a novel method to se...

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Detalles Bibliográficos
Autores principales: Hu, Wenjuan, Chang, Lu, Ke, Changqiang, Xie, Yuanchao, Shen, Jingshan, Tan, Bo, Liu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703390/
https://www.ncbi.nlm.nih.gov/pubmed/33280995
http://dx.doi.org/10.1016/j.jpba.2020.113806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703390/
https://www.ncbi.nlm.nih.gov/pubmed/33280995
http://dx.doi.org/10.1016/j.jpba.2020.113806

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