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Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease
Congenital heart disease (CHD) is one of the major debilitating birth defects resulting in significant impact on neonatal and child mortality globally. The etiology of CHD is complex and multifactorial. Many causative genes responsible for CHDs have been identified from the familial forms previously...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703391/ https://www.ncbi.nlm.nih.gov/pubmed/33294766 http://dx.doi.org/10.1093/cdn/nzaa166 |
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author | Joshi, Radha O Chellappan, Subramanian Kukshal, Prachi |
author_facet | Joshi, Radha O Chellappan, Subramanian Kukshal, Prachi |
author_sort | Joshi, Radha O |
collection | PubMed |
description | Congenital heart disease (CHD) is one of the major debilitating birth defects resulting in significant impact on neonatal and child mortality globally. The etiology of CHD is complex and multifactorial. Many causative genes responsible for CHDs have been identified from the familial forms previously. Still, the non-Mendelian inheritance and predominant sporadic cases have stimulated research to understand the epigenetic basis and environmental impact on the incidence of CHD. The fetal epigenetic programming affecting cardiac development is susceptible to the availability of key dietary factors during the crucial periconceptional period. This article highlights the need and importance of in-depth research in the new emerging area of maternal nutritional epigenetics and CHD. It summarizes the current research and underlines the limitations in these types of studies. This review will benefit the future research on nutrition as a modifiable environmental factor to decrease the incidence of CHD. |
format | Online Article Text |
id | pubmed-7703391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77033912020-12-07 Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease Joshi, Radha O Chellappan, Subramanian Kukshal, Prachi Curr Dev Nutr REVIEW Congenital heart disease (CHD) is one of the major debilitating birth defects resulting in significant impact on neonatal and child mortality globally. The etiology of CHD is complex and multifactorial. Many causative genes responsible for CHDs have been identified from the familial forms previously. Still, the non-Mendelian inheritance and predominant sporadic cases have stimulated research to understand the epigenetic basis and environmental impact on the incidence of CHD. The fetal epigenetic programming affecting cardiac development is susceptible to the availability of key dietary factors during the crucial periconceptional period. This article highlights the need and importance of in-depth research in the new emerging area of maternal nutritional epigenetics and CHD. It summarizes the current research and underlines the limitations in these types of studies. This review will benefit the future research on nutrition as a modifiable environmental factor to decrease the incidence of CHD. Oxford University Press 2020-11-10 /pmc/articles/PMC7703391/ /pubmed/33294766 http://dx.doi.org/10.1093/cdn/nzaa166 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | REVIEW Joshi, Radha O Chellappan, Subramanian Kukshal, Prachi Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease |
title | Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease |
title_full | Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease |
title_fullStr | Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease |
title_full_unstemmed | Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease |
title_short | Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease |
title_sort | exploring the role of maternal nutritional epigenetics in congenital heart disease |
topic | REVIEW |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703391/ https://www.ncbi.nlm.nih.gov/pubmed/33294766 http://dx.doi.org/10.1093/cdn/nzaa166 |
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