Cargando…

Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease

Congenital heart disease (CHD) is one of the major debilitating birth defects resulting in significant impact on neonatal and child mortality globally. The etiology of CHD is complex and multifactorial. Many causative genes responsible for CHDs have been identified from the familial forms previously...

Descripción completa

Detalles Bibliográficos
Autores principales: Joshi, Radha O, Chellappan, Subramanian, Kukshal, Prachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703391/
https://www.ncbi.nlm.nih.gov/pubmed/33294766
http://dx.doi.org/10.1093/cdn/nzaa166
_version_ 1783616628504657920
author Joshi, Radha O
Chellappan, Subramanian
Kukshal, Prachi
author_facet Joshi, Radha O
Chellappan, Subramanian
Kukshal, Prachi
author_sort Joshi, Radha O
collection PubMed
description Congenital heart disease (CHD) is one of the major debilitating birth defects resulting in significant impact on neonatal and child mortality globally. The etiology of CHD is complex and multifactorial. Many causative genes responsible for CHDs have been identified from the familial forms previously. Still, the non-Mendelian inheritance and predominant sporadic cases have stimulated research to understand the epigenetic basis and environmental impact on the incidence of CHD. The fetal epigenetic programming affecting cardiac development is susceptible to the availability of key dietary factors during the crucial periconceptional period. This article highlights the need and importance of in-depth research in the new emerging area of maternal nutritional epigenetics and CHD. It summarizes the current research and underlines the limitations in these types of studies. This review will benefit the future research on nutrition as a modifiable environmental factor to decrease the incidence of CHD.
format Online
Article
Text
id pubmed-7703391
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-77033912020-12-07 Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease Joshi, Radha O Chellappan, Subramanian Kukshal, Prachi Curr Dev Nutr REVIEW Congenital heart disease (CHD) is one of the major debilitating birth defects resulting in significant impact on neonatal and child mortality globally. The etiology of CHD is complex and multifactorial. Many causative genes responsible for CHDs have been identified from the familial forms previously. Still, the non-Mendelian inheritance and predominant sporadic cases have stimulated research to understand the epigenetic basis and environmental impact on the incidence of CHD. The fetal epigenetic programming affecting cardiac development is susceptible to the availability of key dietary factors during the crucial periconceptional period. This article highlights the need and importance of in-depth research in the new emerging area of maternal nutritional epigenetics and CHD. It summarizes the current research and underlines the limitations in these types of studies. This review will benefit the future research on nutrition as a modifiable environmental factor to decrease the incidence of CHD. Oxford University Press 2020-11-10 /pmc/articles/PMC7703391/ /pubmed/33294766 http://dx.doi.org/10.1093/cdn/nzaa166 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle REVIEW
Joshi, Radha O
Chellappan, Subramanian
Kukshal, Prachi
Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease
title Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease
title_full Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease
title_fullStr Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease
title_full_unstemmed Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease
title_short Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease
title_sort exploring the role of maternal nutritional epigenetics in congenital heart disease
topic REVIEW
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703391/
https://www.ncbi.nlm.nih.gov/pubmed/33294766
http://dx.doi.org/10.1093/cdn/nzaa166
work_keys_str_mv AT joshiradhao exploringtheroleofmaternalnutritionalepigeneticsincongenitalheartdisease
AT chellappansubramanian exploringtheroleofmaternalnutritionalepigeneticsincongenitalheartdisease
AT kukshalprachi exploringtheroleofmaternalnutritionalepigeneticsincongenitalheartdisease