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Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis
Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703472/ https://www.ncbi.nlm.nih.gov/pubmed/33283062 http://dx.doi.org/10.1016/j.heliyon.2020.e05635 |
| _version_ | 1783616646399655936 |
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| author | Avendaño-Ortiz, José Lozano-Rodríguez, Roberto Martín-Quirós, Alejandro Maroun-Eid, Charbel Terrón, Verónica Valentín, Jaime Montalbán-Hernández, Karla Ruiz de la Bastida, Fátima García-Garrido, Miguel A. Cubillos-Zapata, Carolina del Balzo-Castillo, Álvaro Aguirre, Luis A. López-Collazo, Eduardo |
| author_facet | Avendaño-Ortiz, José Lozano-Rodríguez, Roberto Martín-Quirós, Alejandro Maroun-Eid, Charbel Terrón, Verónica Valentín, Jaime Montalbán-Hernández, Karla Ruiz de la Bastida, Fátima García-Garrido, Miguel A. Cubillos-Zapata, Carolina del Balzo-Castillo, Álvaro Aguirre, Luis A. López-Collazo, Eduardo |
| author_sort | Avendaño-Ortiz, José |
| collection | PubMed |
| description | Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation. |
| format | Online Article Text |
| id | pubmed-7703472 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77034722020-12-01 Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis Avendaño-Ortiz, José Lozano-Rodríguez, Roberto Martín-Quirós, Alejandro Maroun-Eid, Charbel Terrón, Verónica Valentín, Jaime Montalbán-Hernández, Karla Ruiz de la Bastida, Fátima García-Garrido, Miguel A. Cubillos-Zapata, Carolina del Balzo-Castillo, Álvaro Aguirre, Luis A. López-Collazo, Eduardo Heliyon Research Article Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation. Elsevier 2020-11-30 /pmc/articles/PMC7703472/ /pubmed/33283062 http://dx.doi.org/10.1016/j.heliyon.2020.e05635 Text en © 2020 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Research Article Avendaño-Ortiz, José Lozano-Rodríguez, Roberto Martín-Quirós, Alejandro Maroun-Eid, Charbel Terrón, Verónica Valentín, Jaime Montalbán-Hernández, Karla Ruiz de la Bastida, Fátima García-Garrido, Miguel A. Cubillos-Zapata, Carolina del Balzo-Castillo, Álvaro Aguirre, Luis A. López-Collazo, Eduardo Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis |
| title | Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis |
| title_full | Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis |
| title_fullStr | Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis |
| title_full_unstemmed | Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis |
| title_short | Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis |
| title_sort | proteins from sars-cov-2 reduce t cell proliferation: a mirror image of sepsis |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703472/ https://www.ncbi.nlm.nih.gov/pubmed/33283062 http://dx.doi.org/10.1016/j.heliyon.2020.e05635 |
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