Neutrophils and COVID-19: The road so far

The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyperinflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19...

Descripción completa

Detalles Bibliográficos
Autores principales: Cavalcante-Silva, Luiz Henrique Agra, Carvalho, Deyse Cristina Madruga, Lima, Éssia de Almeida, Galvão, José G.F.M., da Silva, Juliane S. de França, Sales-Neto, José Marreiro de, Rodrigues-Mascarenhas, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703515/
https://www.ncbi.nlm.nih.gov/pubmed/33290963
http://dx.doi.org/10.1016/j.intimp.2020.107233
Descripción
Sumario:The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyperinflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19 immunopathogenesis (e.g., dysfunctional IFN response and myeloid inflammation). In this regard, neutrophils have been highlighted as essential effector cells in the development of COVID-19. This review summarized the significant finds about neutrophils and its effector mechanisms (e.g., neutrophils enzymes and cytokines, neutrophil extracellular traps) in COVID-19 so far.

Ejemplares similares