Neutrophils and COVID-19: The road so far

The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyperinflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19...

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Autores principales: Cavalcante-Silva, Luiz Henrique Agra, Carvalho, Deyse Cristina Madruga, Lima, Éssia de Almeida, Galvão, José G.F.M., da Silva, Juliane S. de França, Sales-Neto, José Marreiro de, Rodrigues-Mascarenhas, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703515/
https://www.ncbi.nlm.nih.gov/pubmed/33290963
http://dx.doi.org/10.1016/j.intimp.2020.107233
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author Cavalcante-Silva, Luiz Henrique Agra
Carvalho, Deyse Cristina Madruga
Lima, Éssia de Almeida
Galvão, José G.F.M.
da Silva, Juliane S. de França
Sales-Neto, José Marreiro de
Rodrigues-Mascarenhas, Sandra
author_facet Cavalcante-Silva, Luiz Henrique Agra
Carvalho, Deyse Cristina Madruga
Lima, Éssia de Almeida
Galvão, José G.F.M.
da Silva, Juliane S. de França
Sales-Neto, José Marreiro de
Rodrigues-Mascarenhas, Sandra
author_sort Cavalcante-Silva, Luiz Henrique Agra
collection PubMed
description The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyperinflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19 immunopathogenesis (e.g., dysfunctional IFN response and myeloid inflammation). In this regard, neutrophils have been highlighted as essential effector cells in the development of COVID-19. This review summarized the significant finds about neutrophils and its effector mechanisms (e.g., neutrophils enzymes and cytokines, neutrophil extracellular traps) in COVID-19 so far.
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spelling pubmed-77035152020-12-01 Neutrophils and COVID-19: The road so far Cavalcante-Silva, Luiz Henrique Agra Carvalho, Deyse Cristina Madruga Lima, Éssia de Almeida Galvão, José G.F.M. da Silva, Juliane S. de França Sales-Neto, José Marreiro de Rodrigues-Mascarenhas, Sandra Int Immunopharmacol Review The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyperinflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19 immunopathogenesis (e.g., dysfunctional IFN response and myeloid inflammation). In this regard, neutrophils have been highlighted as essential effector cells in the development of COVID-19. This review summarized the significant finds about neutrophils and its effector mechanisms (e.g., neutrophils enzymes and cytokines, neutrophil extracellular traps) in COVID-19 so far. Elsevier B.V. 2021-01 2020-11-30 /pmc/articles/PMC7703515/ /pubmed/33290963 http://dx.doi.org/10.1016/j.intimp.2020.107233 Text en © 2020 Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Cavalcante-Silva, Luiz Henrique Agra
Carvalho, Deyse Cristina Madruga
Lima, Éssia de Almeida
Galvão, José G.F.M.
da Silva, Juliane S. de França
Sales-Neto, José Marreiro de
Rodrigues-Mascarenhas, Sandra
Neutrophils and COVID-19: The road so far
title Neutrophils and COVID-19: The road so far
title_full Neutrophils and COVID-19: The road so far
title_fullStr Neutrophils and COVID-19: The road so far
title_full_unstemmed Neutrophils and COVID-19: The road so far
title_short Neutrophils and COVID-19: The road so far
title_sort neutrophils and covid-19: the road so far
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703515/
https://www.ncbi.nlm.nih.gov/pubmed/33290963
http://dx.doi.org/10.1016/j.intimp.2020.107233
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