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Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antib...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculdade de Saúde Pública da Universidade de São Paulo
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703539/ https://www.ncbi.nlm.nih.gov/pubmed/33331525 http://dx.doi.org/10.11606/s1518-8787.2020054003278 |
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author | da Silva, Antônio Augusto Moura Lima-Neto, Lídio Gonçalves de Azevedo, Conceição de Maria Pedrozo e Silva da Costa, Léa Márcia Melo Bragança, Maylla Luanna Barbosa Martins Barros, Allan Kardec Duailibe Wittlin, Bernardo Bastos de Souza, Bruno Feres de Oliveira, Bruno Luciano Carneiro Alves de Carvalho, Carolina Abreu Thomaz, Erika Barbara Abreu Fonseca Simões-Neto, Eudes Alves Leite, Jamesson Ferreira Cosme, Lécia Maria Sousa Santos Campos, Marcos Adriano Garcia Queiroz, Rejane Christine de Sousa Costa, Sérgio Souza de Carvalho, Vitória Abreu Simões, Vanda Maria Ferreira Alves, Maria Teresa Seabra Soares de Brito e dos Santos, Alcione Miranda |
author_facet | da Silva, Antônio Augusto Moura Lima-Neto, Lídio Gonçalves de Azevedo, Conceição de Maria Pedrozo e Silva da Costa, Léa Márcia Melo Bragança, Maylla Luanna Barbosa Martins Barros, Allan Kardec Duailibe Wittlin, Bernardo Bastos de Souza, Bruno Feres de Oliveira, Bruno Luciano Carneiro Alves de Carvalho, Carolina Abreu Thomaz, Erika Barbara Abreu Fonseca Simões-Neto, Eudes Alves Leite, Jamesson Ferreira Cosme, Lécia Maria Sousa Santos Campos, Marcos Adriano Garcia Queiroz, Rejane Christine de Sousa Costa, Sérgio Souza de Carvalho, Vitória Abreu Simões, Vanda Maria Ferreira Alves, Maria Teresa Seabra Soares de Brito e dos Santos, Alcione Miranda |
author_sort | da Silva, Antônio Augusto Moura |
collection | PubMed |
description | OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon. |
format | Online Article Text |
id | pubmed-7703539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Faculdade de Saúde Pública da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-77035392020-12-04 Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão da Silva, Antônio Augusto Moura Lima-Neto, Lídio Gonçalves de Azevedo, Conceição de Maria Pedrozo e Silva da Costa, Léa Márcia Melo Bragança, Maylla Luanna Barbosa Martins Barros, Allan Kardec Duailibe Wittlin, Bernardo Bastos de Souza, Bruno Feres de Oliveira, Bruno Luciano Carneiro Alves de Carvalho, Carolina Abreu Thomaz, Erika Barbara Abreu Fonseca Simões-Neto, Eudes Alves Leite, Jamesson Ferreira Cosme, Lécia Maria Sousa Santos Campos, Marcos Adriano Garcia Queiroz, Rejane Christine de Sousa Costa, Sérgio Souza de Carvalho, Vitória Abreu Simões, Vanda Maria Ferreira Alves, Maria Teresa Seabra Soares de Brito e dos Santos, Alcione Miranda Rev Saude Publica Original Article OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon. Faculdade de Saúde Pública da Universidade de São Paulo 2020-11-27 /pmc/articles/PMC7703539/ /pubmed/33331525 http://dx.doi.org/10.11606/s1518-8787.2020054003278 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article da Silva, Antônio Augusto Moura Lima-Neto, Lídio Gonçalves de Azevedo, Conceição de Maria Pedrozo e Silva da Costa, Léa Márcia Melo Bragança, Maylla Luanna Barbosa Martins Barros, Allan Kardec Duailibe Wittlin, Bernardo Bastos de Souza, Bruno Feres de Oliveira, Bruno Luciano Carneiro Alves de Carvalho, Carolina Abreu Thomaz, Erika Barbara Abreu Fonseca Simões-Neto, Eudes Alves Leite, Jamesson Ferreira Cosme, Lécia Maria Sousa Santos Campos, Marcos Adriano Garcia Queiroz, Rejane Christine de Sousa Costa, Sérgio Souza de Carvalho, Vitória Abreu Simões, Vanda Maria Ferreira Alves, Maria Teresa Seabra Soares de Brito e dos Santos, Alcione Miranda Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title | Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title_full | Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title_fullStr | Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title_full_unstemmed | Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title_short | Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title_sort | population-based seroprevalence of sars-cov-2 and the herd immunity threshold in maranhão |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703539/ https://www.ncbi.nlm.nih.gov/pubmed/33331525 http://dx.doi.org/10.11606/s1518-8787.2020054003278 |
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