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Evidence that coronavirus superspreading is fat-tailed
Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the di...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703634/ https://www.ncbi.nlm.nih.gov/pubmed/33139561 http://dx.doi.org/10.1073/pnas.2018490117 |
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author | Wong, Felix Collins, James J. |
author_facet | Wong, Felix Collins, James J. |
author_sort | Wong, Felix |
collection | PubMed |
description | Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events are extremal, yet probable, occurrences. We integrate these results with interaction-based network models of disease transmission and show that superspreading, when it is fat-tailed, leads to pronounced transmission by increasing dispersion. Our findings indicate that large superspreading events should be the targets of interventions that minimize tail exposure. |
format | Online Article Text |
id | pubmed-7703634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-77036342020-12-10 Evidence that coronavirus superspreading is fat-tailed Wong, Felix Collins, James J. Proc Natl Acad Sci U S A Biological Sciences Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events are extremal, yet probable, occurrences. We integrate these results with interaction-based network models of disease transmission and show that superspreading, when it is fat-tailed, leads to pronounced transmission by increasing dispersion. Our findings indicate that large superspreading events should be the targets of interventions that minimize tail exposure. National Academy of Sciences 2020-11-24 2020-11-02 /pmc/articles/PMC7703634/ /pubmed/33139561 http://dx.doi.org/10.1073/pnas.2018490117 Text en Copyright © 2020 the Author(s). Published by PNAS. http://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Biological Sciences Wong, Felix Collins, James J. Evidence that coronavirus superspreading is fat-tailed |
title | Evidence that coronavirus superspreading is fat-tailed |
title_full | Evidence that coronavirus superspreading is fat-tailed |
title_fullStr | Evidence that coronavirus superspreading is fat-tailed |
title_full_unstemmed | Evidence that coronavirus superspreading is fat-tailed |
title_short | Evidence that coronavirus superspreading is fat-tailed |
title_sort | evidence that coronavirus superspreading is fat-tailed |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703634/ https://www.ncbi.nlm.nih.gov/pubmed/33139561 http://dx.doi.org/10.1073/pnas.2018490117 |
work_keys_str_mv | AT wongfelix evidencethatcoronavirussuperspreadingisfattailed AT collinsjamesj evidencethatcoronavirussuperspreadingisfattailed |