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Evidence that coronavirus superspreading is fat-tailed

Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the di...

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Detalles Bibliográficos
Autores principales: Wong, Felix, Collins, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703634/
https://www.ncbi.nlm.nih.gov/pubmed/33139561
http://dx.doi.org/10.1073/pnas.2018490117
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author Wong, Felix
Collins, James J.
author_facet Wong, Felix
Collins, James J.
author_sort Wong, Felix
collection PubMed
description Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events are extremal, yet probable, occurrences. We integrate these results with interaction-based network models of disease transmission and show that superspreading, when it is fat-tailed, leads to pronounced transmission by increasing dispersion. Our findings indicate that large superspreading events should be the targets of interventions that minimize tail exposure.
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spelling pubmed-77036342020-12-10 Evidence that coronavirus superspreading is fat-tailed Wong, Felix Collins, James J. Proc Natl Acad Sci U S A Biological Sciences Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events are extremal, yet probable, occurrences. We integrate these results with interaction-based network models of disease transmission and show that superspreading, when it is fat-tailed, leads to pronounced transmission by increasing dispersion. Our findings indicate that large superspreading events should be the targets of interventions that minimize tail exposure. National Academy of Sciences 2020-11-24 2020-11-02 /pmc/articles/PMC7703634/ /pubmed/33139561 http://dx.doi.org/10.1073/pnas.2018490117 Text en Copyright © 2020 the Author(s). Published by PNAS. http://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biological Sciences
Wong, Felix
Collins, James J.
Evidence that coronavirus superspreading is fat-tailed
title Evidence that coronavirus superspreading is fat-tailed
title_full Evidence that coronavirus superspreading is fat-tailed
title_fullStr Evidence that coronavirus superspreading is fat-tailed
title_full_unstemmed Evidence that coronavirus superspreading is fat-tailed
title_short Evidence that coronavirus superspreading is fat-tailed
title_sort evidence that coronavirus superspreading is fat-tailed
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703634/
https://www.ncbi.nlm.nih.gov/pubmed/33139561
http://dx.doi.org/10.1073/pnas.2018490117
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AT collinsjamesj evidencethatcoronavirussuperspreadingisfattailed