Modelling intestinal inflammation and infection using ‘mini-gut’ organoids

In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using ‘mini-gut’ organoids. Key findings include the discovery of somatic inflammatory gene mutations in ulcerative colitis epithelium, a unique mutational signature in colorectal canc...

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Detalles Bibliográficos
Autor principal: Li, Vivian S. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Year in Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703732/
https://www.ncbi.nlm.nih.gov/pubmed/33257835
http://dx.doi.org/10.1038/s41575-020-00391-4
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author Li, Vivian S. W.
author_facet Li, Vivian S. W.
author_sort Li, Vivian S. W.
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description In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using ‘mini-gut’ organoids. Key findings include the discovery of somatic inflammatory gene mutations in ulcerative colitis epithelium, a unique mutational signature in colorectal cancer caused by genotoxic Escherichia coli, and infection of intestinal organoids by SARS-CoV-2.
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spelling pubmed-77037322020-12-01 Modelling intestinal inflammation and infection using ‘mini-gut’ organoids Li, Vivian S. W. Nat Rev Gastroenterol Hepatol Year in Review In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using ‘mini-gut’ organoids. Key findings include the discovery of somatic inflammatory gene mutations in ulcerative colitis epithelium, a unique mutational signature in colorectal cancer caused by genotoxic Escherichia coli, and infection of intestinal organoids by SARS-CoV-2. Nature Publishing Group UK 2020-11-30 2021 /pmc/articles/PMC7703732/ /pubmed/33257835 http://dx.doi.org/10.1038/s41575-020-00391-4 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Year in Review
Li, Vivian S. W.
Modelling intestinal inflammation and infection using ‘mini-gut’ organoids
title Modelling intestinal inflammation and infection using ‘mini-gut’ organoids
title_full Modelling intestinal inflammation and infection using ‘mini-gut’ organoids
title_fullStr Modelling intestinal inflammation and infection using ‘mini-gut’ organoids
title_full_unstemmed Modelling intestinal inflammation and infection using ‘mini-gut’ organoids
title_short Modelling intestinal inflammation and infection using ‘mini-gut’ organoids
title_sort modelling intestinal inflammation and infection using ‘mini-gut’ organoids
topic Year in Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703732/
https://www.ncbi.nlm.nih.gov/pubmed/33257835
http://dx.doi.org/10.1038/s41575-020-00391-4
work_keys_str_mv AT liviviansw modellingintestinalinflammationandinfectionusingminigutorganoids

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