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EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes
MOTIVATION: The evolution and role of gene clusters in eukaryotes is poorly understood. Currently, most studies and computational prediction programs limit their focus to specific types of clusters, such as those involved in secondary metabolism. RESULTS: We present EvolClust, a python-based tool fo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703780/ https://www.ncbi.nlm.nih.gov/pubmed/31560365 http://dx.doi.org/10.1093/bioinformatics/btz706 |
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author | Marcet-Houben, Marina Gabaldón, Toni |
author_facet | Marcet-Houben, Marina Gabaldón, Toni |
author_sort | Marcet-Houben, Marina |
collection | PubMed |
description | MOTIVATION: The evolution and role of gene clusters in eukaryotes is poorly understood. Currently, most studies and computational prediction programs limit their focus to specific types of clusters, such as those involved in secondary metabolism. RESULTS: We present EvolClust, a python-based tool for the inference of evolutionary conserved gene clusters from genome comparisons, independently of the function or gene composition of the cluster. EvolClust predicts conserved gene clusters from pairwise genome comparisons and infers families of related clusters from multiple (all versus all) genome comparisons. AVAILABILITY AND IMPLEMENTATION: https://github.com/Gabaldonlab/EvolClust/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. |
format | Online Article Text |
id | pubmed-7703780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77037802020-12-07 EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes Marcet-Houben, Marina Gabaldón, Toni Bioinformatics Applications Notes MOTIVATION: The evolution and role of gene clusters in eukaryotes is poorly understood. Currently, most studies and computational prediction programs limit their focus to specific types of clusters, such as those involved in secondary metabolism. RESULTS: We present EvolClust, a python-based tool for the inference of evolutionary conserved gene clusters from genome comparisons, independently of the function or gene composition of the cluster. EvolClust predicts conserved gene clusters from pairwise genome comparisons and infers families of related clusters from multiple (all versus all) genome comparisons. AVAILABILITY AND IMPLEMENTATION: https://github.com/Gabaldonlab/EvolClust/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. Oxford University Press 2020-02-15 2019-09-27 /pmc/articles/PMC7703780/ /pubmed/31560365 http://dx.doi.org/10.1093/bioinformatics/btz706 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Applications Notes Marcet-Houben, Marina Gabaldón, Toni EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes |
title | EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes |
title_full | EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes |
title_fullStr | EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes |
title_full_unstemmed | EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes |
title_short | EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes |
title_sort | evolclust: automated inference of evolutionary conserved gene clusters in eukaryotes |
topic | Applications Notes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703780/ https://www.ncbi.nlm.nih.gov/pubmed/31560365 http://dx.doi.org/10.1093/bioinformatics/btz706 |
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