Cargando…

EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes

MOTIVATION: The evolution and role of gene clusters in eukaryotes is poorly understood. Currently, most studies and computational prediction programs limit their focus to specific types of clusters, such as those involved in secondary metabolism. RESULTS: We present EvolClust, a python-based tool fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Marcet-Houben, Marina, Gabaldón, Toni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703780/
https://www.ncbi.nlm.nih.gov/pubmed/31560365
http://dx.doi.org/10.1093/bioinformatics/btz706
_version_ 1783616694736912384
author Marcet-Houben, Marina
Gabaldón, Toni
author_facet Marcet-Houben, Marina
Gabaldón, Toni
author_sort Marcet-Houben, Marina
collection PubMed
description MOTIVATION: The evolution and role of gene clusters in eukaryotes is poorly understood. Currently, most studies and computational prediction programs limit their focus to specific types of clusters, such as those involved in secondary metabolism. RESULTS: We present EvolClust, a python-based tool for the inference of evolutionary conserved gene clusters from genome comparisons, independently of the function or gene composition of the cluster. EvolClust predicts conserved gene clusters from pairwise genome comparisons and infers families of related clusters from multiple (all versus all) genome comparisons. AVAILABILITY AND IMPLEMENTATION: https://github.com/Gabaldonlab/EvolClust/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
format Online
Article
Text
id pubmed-7703780
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-77037802020-12-07 EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes Marcet-Houben, Marina Gabaldón, Toni Bioinformatics Applications Notes MOTIVATION: The evolution and role of gene clusters in eukaryotes is poorly understood. Currently, most studies and computational prediction programs limit their focus to specific types of clusters, such as those involved in secondary metabolism. RESULTS: We present EvolClust, a python-based tool for the inference of evolutionary conserved gene clusters from genome comparisons, independently of the function or gene composition of the cluster. EvolClust predicts conserved gene clusters from pairwise genome comparisons and infers families of related clusters from multiple (all versus all) genome comparisons. AVAILABILITY AND IMPLEMENTATION: https://github.com/Gabaldonlab/EvolClust/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. Oxford University Press 2020-02-15 2019-09-27 /pmc/articles/PMC7703780/ /pubmed/31560365 http://dx.doi.org/10.1093/bioinformatics/btz706 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Applications Notes
Marcet-Houben, Marina
Gabaldón, Toni
EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes
title EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes
title_full EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes
title_fullStr EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes
title_full_unstemmed EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes
title_short EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes
title_sort evolclust: automated inference of evolutionary conserved gene clusters in eukaryotes
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703780/
https://www.ncbi.nlm.nih.gov/pubmed/31560365
http://dx.doi.org/10.1093/bioinformatics/btz706
work_keys_str_mv AT marcethoubenmarina evolclustautomatedinferenceofevolutionaryconservedgeneclustersineukaryotes
AT gabaldontoni evolclustautomatedinferenceofevolutionaryconservedgeneclustersineukaryotes