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Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer
INTRODUCTION: Radiation-induced lymphopenia (RIL) occurs during treatment with conventional radiation in multiple organ sites. Development of RIL portends poor prognosis. Stereotactic body radiation therapy (SBRT) spares RIL in pancreatic cancer, but has not been examined in other sites commonly tre...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703900/ https://www.ncbi.nlm.nih.gov/pubmed/33253196 http://dx.doi.org/10.1371/journal.pone.0241505 |
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author | McLaughlin, Mark F. Alam, Morshed Smith, Lynnette Ryckman, Jeffrey Lin, Chi Baine, Michael J. |
author_facet | McLaughlin, Mark F. Alam, Morshed Smith, Lynnette Ryckman, Jeffrey Lin, Chi Baine, Michael J. |
author_sort | McLaughlin, Mark F. |
collection | PubMed |
description | INTRODUCTION: Radiation-induced lymphopenia (RIL) occurs during treatment with conventional radiation in multiple organ sites. Development of RIL portends poor prognosis. Stereotactic body radiation therapy (SBRT) spares RIL in pancreatic cancer, but has not been examined in other sites commonly treated with SBRT. This work examines if SBRT similarly spares RIL in patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Retrospective analysis was done at a single institution on 40 distinct cases of SBRT for early stage NSCLC from 2006–2017. Incidentally collected lymphocyte counts collected within 6 months of SBRT treatment were analyzed to determine if RIL occurred. The presence of RIL was correlated with location of initial failure and survival endpoints. Kaplan-Meier curves were constructed with significance defined at the level p < 0.05. RESULTS: RIL was observed in 35% of the analyzed patients. Patterns of failure and survival data were comparable to prior SBRT literature. There was no observed association in two year local, nodal, or distant failure, progression free survival, or overall survival based on the presence of RIL. DISCUSSION: SBRT spares RIL in NSCLC compared to historical rates observed with conventionally fractionated radiation. As understanding of the role of the immune system in cancer control continues to evolve, the importance of RIL sparing techniques take on increasing importance. This study represents further analysis of RIL sparing in SBRT in an early stage NSCLC cohort without the confounding influence of chemotherapy. |
format | Online Article Text |
id | pubmed-7703900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77039002020-12-03 Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer McLaughlin, Mark F. Alam, Morshed Smith, Lynnette Ryckman, Jeffrey Lin, Chi Baine, Michael J. PLoS One Research Article INTRODUCTION: Radiation-induced lymphopenia (RIL) occurs during treatment with conventional radiation in multiple organ sites. Development of RIL portends poor prognosis. Stereotactic body radiation therapy (SBRT) spares RIL in pancreatic cancer, but has not been examined in other sites commonly treated with SBRT. This work examines if SBRT similarly spares RIL in patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Retrospective analysis was done at a single institution on 40 distinct cases of SBRT for early stage NSCLC from 2006–2017. Incidentally collected lymphocyte counts collected within 6 months of SBRT treatment were analyzed to determine if RIL occurred. The presence of RIL was correlated with location of initial failure and survival endpoints. Kaplan-Meier curves were constructed with significance defined at the level p < 0.05. RESULTS: RIL was observed in 35% of the analyzed patients. Patterns of failure and survival data were comparable to prior SBRT literature. There was no observed association in two year local, nodal, or distant failure, progression free survival, or overall survival based on the presence of RIL. DISCUSSION: SBRT spares RIL in NSCLC compared to historical rates observed with conventionally fractionated radiation. As understanding of the role of the immune system in cancer control continues to evolve, the importance of RIL sparing techniques take on increasing importance. This study represents further analysis of RIL sparing in SBRT in an early stage NSCLC cohort without the confounding influence of chemotherapy. Public Library of Science 2020-11-30 /pmc/articles/PMC7703900/ /pubmed/33253196 http://dx.doi.org/10.1371/journal.pone.0241505 Text en © 2020 McLaughlin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article McLaughlin, Mark F. Alam, Morshed Smith, Lynnette Ryckman, Jeffrey Lin, Chi Baine, Michael J. Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer |
title | Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer |
title_full | Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer |
title_fullStr | Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer |
title_full_unstemmed | Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer |
title_short | Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer |
title_sort | stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703900/ https://www.ncbi.nlm.nih.gov/pubmed/33253196 http://dx.doi.org/10.1371/journal.pone.0241505 |
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