Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction

RATIONALE: The beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults. To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury. This observation has been repeated by multiple gr...

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Detalles Bibliográficos
Autores principales: Dassanayaka, Sujith, Brittian, Kenneth R., Long, Bethany W., Higgins, Lauren A., Bradley, James A., Audam, Timothy N., Jurkovic, Andrea, Gumpert, Anna M., Harrison, Linda T., Hartyánszky, István, Perge, Péter, Merkely, Béla, Radovits, Tamás, Hanover, John A., Jones, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703924/
https://www.ncbi.nlm.nih.gov/pubmed/33253217
http://dx.doi.org/10.1371/journal.pone.0242250

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