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Genetic and reproductive consequences of consanguineous marriage in Bangladesh
INTRODUCTION: This study aimed to assess the prevalence, sociodemographic factors, reproductive consequences, and heritable disease burdens associated with consanguineous marriage (CM) in Bangladesh. METHODS: A total of 7,312 families, including 3,694 CM-families, were recruited from 102 locales of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703949/ https://www.ncbi.nlm.nih.gov/pubmed/33253173 http://dx.doi.org/10.1371/journal.pone.0241610 |
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author | Anwar, Saeed Taslem Mourosi, Jarin Arafat, Yasir Hosen, Mohammad Jakir |
author_facet | Anwar, Saeed Taslem Mourosi, Jarin Arafat, Yasir Hosen, Mohammad Jakir |
author_sort | Anwar, Saeed |
collection | PubMed |
description | INTRODUCTION: This study aimed to assess the prevalence, sociodemographic factors, reproductive consequences, and heritable disease burdens associated with consanguineous marriage (CM) in Bangladesh. METHODS: A total of 7,312 families, including 3,694 CM-families, were recruited from 102 locales of 58 districts of Bangladesh. Using a standard questionnaire, we collected medical history and background sociodemographic data of these families. Family history was assessed by pedigree analysis. Fertility, mortality, secondary sex ratio, selection intensity, lethal equivalents were measured using standard methods. RESULTS: The mean prevalence of CM in our studied population was 6.64%. Gross fertility was higher among CM families, as compared to the non-CM families (p < 0.05). The rate of under-5 child (U5) mortality was significantly higher among CM families (16.6%) in comparison with the non-CM families (5.8%) (p < 0.01). We observed a persuasive rise of abortion/miscarriage and U5 mortality rates with the increasing level of inbreeding. The value of lethal equivalents per gamete found elevated for autosomal inheritances as compared to sex-linked inheritance. CM was associated with the incidence of several single-gene and multifactorial diseases, and congenital malformations, including bronchial asthma, hearing defect, heart diseases, sickle cell anemia (p < 0.05). The general attitude and perception toward CM were rather indifferent, and very few people were concerned about its genetic burden. CONCLUSION: This study highlights the harmful consequences of CM on reproductive behavior and the incidence of hereditary conditions. It essences the need for genetic counseling from premarital to postnatal levels in Bangladesh. |
format | Online Article Text |
id | pubmed-7703949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77039492020-12-03 Genetic and reproductive consequences of consanguineous marriage in Bangladesh Anwar, Saeed Taslem Mourosi, Jarin Arafat, Yasir Hosen, Mohammad Jakir PLoS One Research Article INTRODUCTION: This study aimed to assess the prevalence, sociodemographic factors, reproductive consequences, and heritable disease burdens associated with consanguineous marriage (CM) in Bangladesh. METHODS: A total of 7,312 families, including 3,694 CM-families, were recruited from 102 locales of 58 districts of Bangladesh. Using a standard questionnaire, we collected medical history and background sociodemographic data of these families. Family history was assessed by pedigree analysis. Fertility, mortality, secondary sex ratio, selection intensity, lethal equivalents were measured using standard methods. RESULTS: The mean prevalence of CM in our studied population was 6.64%. Gross fertility was higher among CM families, as compared to the non-CM families (p < 0.05). The rate of under-5 child (U5) mortality was significantly higher among CM families (16.6%) in comparison with the non-CM families (5.8%) (p < 0.01). We observed a persuasive rise of abortion/miscarriage and U5 mortality rates with the increasing level of inbreeding. The value of lethal equivalents per gamete found elevated for autosomal inheritances as compared to sex-linked inheritance. CM was associated with the incidence of several single-gene and multifactorial diseases, and congenital malformations, including bronchial asthma, hearing defect, heart diseases, sickle cell anemia (p < 0.05). The general attitude and perception toward CM were rather indifferent, and very few people were concerned about its genetic burden. CONCLUSION: This study highlights the harmful consequences of CM on reproductive behavior and the incidence of hereditary conditions. It essences the need for genetic counseling from premarital to postnatal levels in Bangladesh. Public Library of Science 2020-11-30 /pmc/articles/PMC7703949/ /pubmed/33253173 http://dx.doi.org/10.1371/journal.pone.0241610 Text en © 2020 Anwar et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Anwar, Saeed Taslem Mourosi, Jarin Arafat, Yasir Hosen, Mohammad Jakir Genetic and reproductive consequences of consanguineous marriage in Bangladesh |
title | Genetic and reproductive consequences of consanguineous marriage in Bangladesh |
title_full | Genetic and reproductive consequences of consanguineous marriage in Bangladesh |
title_fullStr | Genetic and reproductive consequences of consanguineous marriage in Bangladesh |
title_full_unstemmed | Genetic and reproductive consequences of consanguineous marriage in Bangladesh |
title_short | Genetic and reproductive consequences of consanguineous marriage in Bangladesh |
title_sort | genetic and reproductive consequences of consanguineous marriage in bangladesh |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703949/ https://www.ncbi.nlm.nih.gov/pubmed/33253173 http://dx.doi.org/10.1371/journal.pone.0241610 |
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