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Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders

An opaque fetal membrane based on gross appearance is traditionally indicative of histological chorioamnionitis; however, to the best of our knowledge, there is currently no supportive evidence, and its diagnostic efficiency has not yet been scientifically demonstrated. The present study aimed to pr...

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Autores principales: Horikoshi, Yoshimasa, Yaguchi, Chizuko, Furuta-Isomura, Naomi, Itoh, Toshiya, Kawai, Kenta, Oda, Tomoaki, Matsumoto, Masako, Kohmura-Kobayashi, Yukiko, Tamura, Naoaki, Uchida, Toshiyuki, Kanayama, Naohiro, Itoh, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704006/
https://www.ncbi.nlm.nih.gov/pubmed/33253176
http://dx.doi.org/10.1371/journal.pone.0242579
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author Horikoshi, Yoshimasa
Yaguchi, Chizuko
Furuta-Isomura, Naomi
Itoh, Toshiya
Kawai, Kenta
Oda, Tomoaki
Matsumoto, Masako
Kohmura-Kobayashi, Yukiko
Tamura, Naoaki
Uchida, Toshiyuki
Kanayama, Naohiro
Itoh, Hiroaki
author_facet Horikoshi, Yoshimasa
Yaguchi, Chizuko
Furuta-Isomura, Naomi
Itoh, Toshiya
Kawai, Kenta
Oda, Tomoaki
Matsumoto, Masako
Kohmura-Kobayashi, Yukiko
Tamura, Naoaki
Uchida, Toshiyuki
Kanayama, Naohiro
Itoh, Hiroaki
author_sort Horikoshi, Yoshimasa
collection PubMed
description An opaque fetal membrane based on gross appearance is traditionally indicative of histological chorioamnionitis; however, to the best of our knowledge, there is currently no supportive evidence, and its diagnostic efficiency has not yet been scientifically demonstrated. The present study aimed to provide scientific insights into the traditional concept of an opaque fetal membrane based on gross appearance being an indicator of histological chorioamnionitis. We examined the placental pathology after screening of the placental gross appearance and perinatal complications and did not examine uncomplicated deliveries. We investigated the relationship between the presence of an opaque fetal membrane and histological chorioamnionitis (Cohort 1, 571 placentas) or the outcomes of neonates delivered at term (Cohort 2, 409 placentas) at Hamamatsu University School of Medicine between 2010 and 2017. The judgment of a positive opaque fetal membrane based on gross appearance correlated with histological chorioamnionitis (Cohort 1). Its sensitivity and specificity were 66.7 and 89.9%, respectively, while positive and negative predictive values were 86.8 and 73.0%, respectively. The judgment of a positive opaque fetal membrane based on gross appearance significantly correlated with chorioamnionitis-related complications in term newborns after adjustments for confounding factors (OR;1.82 [1.07–3.11], P<0.05) (Cohort 2). A correlation was observed even after adjustments for confounding factors. The present study is the first to demonstrate that the judgment of a positive opaque fetal membrane based on gross appearance correlated with histological chorioamnionitis as well as chorioamnionitis-related complications in newborns delivered at term. The present results provide support for the traditionally-described importance of gross inspections for an opaque fetal membrane soon after birth.
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spelling pubmed-77040062020-12-03 Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders Horikoshi, Yoshimasa Yaguchi, Chizuko Furuta-Isomura, Naomi Itoh, Toshiya Kawai, Kenta Oda, Tomoaki Matsumoto, Masako Kohmura-Kobayashi, Yukiko Tamura, Naoaki Uchida, Toshiyuki Kanayama, Naohiro Itoh, Hiroaki PLoS One Research Article An opaque fetal membrane based on gross appearance is traditionally indicative of histological chorioamnionitis; however, to the best of our knowledge, there is currently no supportive evidence, and its diagnostic efficiency has not yet been scientifically demonstrated. The present study aimed to provide scientific insights into the traditional concept of an opaque fetal membrane based on gross appearance being an indicator of histological chorioamnionitis. We examined the placental pathology after screening of the placental gross appearance and perinatal complications and did not examine uncomplicated deliveries. We investigated the relationship between the presence of an opaque fetal membrane and histological chorioamnionitis (Cohort 1, 571 placentas) or the outcomes of neonates delivered at term (Cohort 2, 409 placentas) at Hamamatsu University School of Medicine between 2010 and 2017. The judgment of a positive opaque fetal membrane based on gross appearance correlated with histological chorioamnionitis (Cohort 1). Its sensitivity and specificity were 66.7 and 89.9%, respectively, while positive and negative predictive values were 86.8 and 73.0%, respectively. The judgment of a positive opaque fetal membrane based on gross appearance significantly correlated with chorioamnionitis-related complications in term newborns after adjustments for confounding factors (OR;1.82 [1.07–3.11], P<0.05) (Cohort 2). A correlation was observed even after adjustments for confounding factors. The present study is the first to demonstrate that the judgment of a positive opaque fetal membrane based on gross appearance correlated with histological chorioamnionitis as well as chorioamnionitis-related complications in newborns delivered at term. The present results provide support for the traditionally-described importance of gross inspections for an opaque fetal membrane soon after birth. Public Library of Science 2020-11-30 /pmc/articles/PMC7704006/ /pubmed/33253176 http://dx.doi.org/10.1371/journal.pone.0242579 Text en © 2020 Horikoshi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Horikoshi, Yoshimasa
Yaguchi, Chizuko
Furuta-Isomura, Naomi
Itoh, Toshiya
Kawai, Kenta
Oda, Tomoaki
Matsumoto, Masako
Kohmura-Kobayashi, Yukiko
Tamura, Naoaki
Uchida, Toshiyuki
Kanayama, Naohiro
Itoh, Hiroaki
Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders
title Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders
title_full Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders
title_fullStr Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders
title_full_unstemmed Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders
title_short Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders
title_sort gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704006/
https://www.ncbi.nlm.nih.gov/pubmed/33253176
http://dx.doi.org/10.1371/journal.pone.0242579
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