A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell’s viper antivenom in Myanmar

For most antivenoms there is little information from clinical studies to infer the relationship between dose and efficacy or dose and toxicity. Antivenom dose-finding studies usually recruit too few patients (e.g. fewer than 20) relative to clinically significant event rates (e.g. 5%). Model based a...

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Detalles Bibliográficos
Autores principales: Watson, James A., Lamb, Thomas, Holmes, Jane, Warrell, David A., Thwin, Khin Thida, Aung, Zaw Lynn, Oo, Min Zaw, Nwe, Myat Thet, Smithuis, Frank, Ashley, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704047/
https://www.ncbi.nlm.nih.gov/pubmed/33196672
http://dx.doi.org/10.1371/journal.pntd.0008109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704047/
https://www.ncbi.nlm.nih.gov/pubmed/33196672
http://dx.doi.org/10.1371/journal.pntd.0008109

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