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Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

Transcriptional memory allows certain genes to respond to previously experienced signals more robustly. However, whether and how the key proinflammatory cytokine TNF-α mediates transcriptional memory are poorly understood. Using HEK293F cells as a model system, we report that sustained TNF-α stimula...

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Detalles Bibliográficos
Autores principales:	Zhao, Zuodong, Zhang, Zhuqiang, Li, Jingjing, Dong, Qiang, Xiong, Jun, Li, Yingfeng, Lan, Mengying, Li, Gang, Zhu, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704108/ https://www.ncbi.nlm.nih.gov/pubmed/33155547 http://dx.doi.org/10.7554/eLife.61965

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