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Effects of gentaminoseleferon on blood parameters during treatment of Mycoplasma dispar respiratory infection in calves
BACKGROUND AND AIM: Respiratory diseases in young cattle are among the significant cattle pathologies that cause considerable economic damage globally. For the treatment of respiratory diseases, coformulated drugs that increase general nonspecific resistance, exhibit adaptogenic and anti-inflammator...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Veterinary World
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704319/ https://www.ncbi.nlm.nih.gov/pubmed/33281356 http://dx.doi.org/10.14202/vetworld.2020.2197-2202 |
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author | Alhussen, Mohammad Abed Naef, Hamdan Vatnikov, Yury Anatolyevich |
author_facet | Alhussen, Mohammad Abed Naef, Hamdan Vatnikov, Yury Anatolyevich |
author_sort | Alhussen, Mohammad Abed |
collection | PubMed |
description | BACKGROUND AND AIM: Respiratory diseases in young cattle are among the significant cattle pathologies that cause considerable economic damage globally. For the treatment of respiratory diseases, coformulated drugs that increase general nonspecific resistance, exhibit adaptogenic and anti-inflammatory properties, and normalize metabolic processes in animals are currently being used. The aim of our study was to investigate the therapeutic efficacy of the complex drug “gentaminoseleferon,” used in the treatment of respiratory diseases in calves, especially in Mycoplasma dispar infection. MATERIALS AND METHODS: The animals were divided into three groups. Calves with the first clinical signs of respiratory pathology were randomly divided into two groups. The first experimental group (n=5) was intramuscularly injected with sulfetrisan at a dose of 5-10 mL/animal once per day for 7 days. The second experimental group (n=5) was given gentaminoseleferon at a dose of 1 mL/10 kg of body weight once per day for 7 days. The drugs were not used in the control group, the “healthy animals (n=5).” Blood samples were taken 10 days before and after treatment and compared between the experimental and healthy calves. The changes in the hematological and biochemical parameters of blood and serum were evaluated. RESULTS: During the recovery process of animals in the experimental groups, a normalization of the hematological and biochemical parameters of blood and serum was noted. Interestingly, in calves of the second experimental group, an increase in the total serum protein content by 2.2% (p<0.05) was recorded in comparison with the first group. The second group, furthermore, showed an increase in Vitamins A, E, and C concentrations by 13.5% (p<0.05), 11.9% (p<0.005), and 15.1% (p<0.0005), respectively, as well as in zinc and iron concentrations by 4.1% (p<0.05) and 9.3% (p<0.0001), respectively. These findings indicate a more pronounced decrease in the inflammatory process in the respiratory system and intensive restoration of metabolism, thereby establishing the high therapeutic efficacy of gentaminoseleferon. CONCLUSION: Gentaminoseleferon was proven highly effective in the treatment of calves with respiratory illnesses and in restoring homeostasis in the organisms of animals after treatment, as indicated by the normalization of morphological and biochemical blood parameters with a reduction in the recovery time. |
format | Online Article Text |
id | pubmed-7704319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Veterinary World |
record_format | MEDLINE/PubMed |
spelling | pubmed-77043192020-12-05 Effects of gentaminoseleferon on blood parameters during treatment of Mycoplasma dispar respiratory infection in calves Alhussen, Mohammad Abed Naef, Hamdan Vatnikov, Yury Anatolyevich Vet World Research Article BACKGROUND AND AIM: Respiratory diseases in young cattle are among the significant cattle pathologies that cause considerable economic damage globally. For the treatment of respiratory diseases, coformulated drugs that increase general nonspecific resistance, exhibit adaptogenic and anti-inflammatory properties, and normalize metabolic processes in animals are currently being used. The aim of our study was to investigate the therapeutic efficacy of the complex drug “gentaminoseleferon,” used in the treatment of respiratory diseases in calves, especially in Mycoplasma dispar infection. MATERIALS AND METHODS: The animals were divided into three groups. Calves with the first clinical signs of respiratory pathology were randomly divided into two groups. The first experimental group (n=5) was intramuscularly injected with sulfetrisan at a dose of 5-10 mL/animal once per day for 7 days. The second experimental group (n=5) was given gentaminoseleferon at a dose of 1 mL/10 kg of body weight once per day for 7 days. The drugs were not used in the control group, the “healthy animals (n=5).” Blood samples were taken 10 days before and after treatment and compared between the experimental and healthy calves. The changes in the hematological and biochemical parameters of blood and serum were evaluated. RESULTS: During the recovery process of animals in the experimental groups, a normalization of the hematological and biochemical parameters of blood and serum was noted. Interestingly, in calves of the second experimental group, an increase in the total serum protein content by 2.2% (p<0.05) was recorded in comparison with the first group. The second group, furthermore, showed an increase in Vitamins A, E, and C concentrations by 13.5% (p<0.05), 11.9% (p<0.005), and 15.1% (p<0.0005), respectively, as well as in zinc and iron concentrations by 4.1% (p<0.05) and 9.3% (p<0.0001), respectively. These findings indicate a more pronounced decrease in the inflammatory process in the respiratory system and intensive restoration of metabolism, thereby establishing the high therapeutic efficacy of gentaminoseleferon. CONCLUSION: Gentaminoseleferon was proven highly effective in the treatment of calves with respiratory illnesses and in restoring homeostasis in the organisms of animals after treatment, as indicated by the normalization of morphological and biochemical blood parameters with a reduction in the recovery time. Veterinary World 2020-10 2020-10-21 /pmc/articles/PMC7704319/ /pubmed/33281356 http://dx.doi.org/10.14202/vetworld.2020.2197-2202 Text en Copyright: © Abed Alhussen, et al. http://creativecommons.org/licenses/by/4.0 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Alhussen, Mohammad Abed Naef, Hamdan Vatnikov, Yury Anatolyevich Effects of gentaminoseleferon on blood parameters during treatment of Mycoplasma dispar respiratory infection in calves |
title | Effects of gentaminoseleferon on blood parameters during treatment of Mycoplasma dispar respiratory infection in calves |
title_full | Effects of gentaminoseleferon on blood parameters during treatment of Mycoplasma dispar respiratory infection in calves |
title_fullStr | Effects of gentaminoseleferon on blood parameters during treatment of Mycoplasma dispar respiratory infection in calves |
title_full_unstemmed | Effects of gentaminoseleferon on blood parameters during treatment of Mycoplasma dispar respiratory infection in calves |
title_short | Effects of gentaminoseleferon on blood parameters during treatment of Mycoplasma dispar respiratory infection in calves |
title_sort | effects of gentaminoseleferon on blood parameters during treatment of mycoplasma dispar respiratory infection in calves |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704319/ https://www.ncbi.nlm.nih.gov/pubmed/33281356 http://dx.doi.org/10.14202/vetworld.2020.2197-2202 |
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