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The atypical neuroleptics iloperidone and lurasidone inhibit human cytochrome P450 enzymes in vitro. Evaluation of potential metabolic interactions

BACKGROUND: The present study aimed at examining the inhibitory effect of two atypical neuroleptics iloperidone and lurasidone on the main human cytochrome P450 (CYP) enzymes in pooled human liver microsomes and cDNA-expressed CYP enzymes (supersomes). METHODS: The activity of these enzymes was dete...

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Detalles Bibliográficos
Autores principales:	Danek, Przemysław J., Wójcikowski, Jacek, Daniel, Władysława A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704495/ https://www.ncbi.nlm.nih.gov/pubmed/32279279 http://dx.doi.org/10.1007/s43440-020-00102-5

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