CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer

The efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the tumor microenvironment (TME). Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for the Kras(LSL−G12D/+)Tp53(fl/fl) (KP) and the Kras(LSL−G12D/+)Lkb1(fl/fl) (KL) NSCLC mouse models by rec...

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Detalles Bibliográficos
Autores principales: Zhang, Man, Yang, Wei, Wang, Peng, Deng, Yu, Dong, Yu-Ting, Liu, Fang-Fang, Huang, Rui, Zhang, Peng, Duan, Ya-Qi, Liu, Xin-Dong, Lin, Dandan, Chu, Qian, Zhong, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704643/
https://www.ncbi.nlm.nih.gov/pubmed/33257678
http://dx.doi.org/10.1038/s41467-020-19973-6

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