A Functional Screening Strategy for Engineering Chimeric Antigen Receptors with Reduced On-Target, Off-Tumor Activation

In recent years, chimeric antigen receptor (CAR) T cell cancer immunotherapies have advanced substantially in the clinic. However, challenges related to safety persist; one major concern occurs when CARs trigger a response to antigen present on healthy cells (on-target, off-tumor response). A strate...

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Detalles Bibliográficos
Autores principales: Di Roberto, Raphaël B., Castellanos-Rueda, Rocío, Frey, Samara, Egli, David, Vazquez-Lombardi, Rodrigo, Kapetanovic, Edo, Kucharczyk, Jakub, Reddy, Sai T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704745/
https://www.ncbi.nlm.nih.gov/pubmed/32827460
http://dx.doi.org/10.1016/j.ymthe.2020.08.003

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