Evolutionary insights into heart regeneration

Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte polyploidy, endothermy, and injury-induced activation of certain transcriptional factors includ...

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Autor principal: Xiong, Jing-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2020
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704876/
https://www.ncbi.nlm.nih.gov/pubmed/33258016
http://dx.doi.org/10.1186/s13619-020-00069-x
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author Xiong, Jing-Wei
author_facet Xiong, Jing-Wei
author_sort Xiong, Jing-Wei
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description Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte polyploidy, endothermy, and injury-induced activation of certain transcriptional factors including AP1 complexes are critical for cardiomyocyte proliferation and heart regeneration during animal evolution. Gaining insights into these evolutionarily conserved mechanisms will likely lead to achieving heart regeneration in non-regenerative mammals including humans.
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spelling pubmed-77048762020-12-03 Evolutionary insights into heart regeneration Xiong, Jing-Wei Cell Regen Opinion Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte polyploidy, endothermy, and injury-induced activation of certain transcriptional factors including AP1 complexes are critical for cardiomyocyte proliferation and heart regeneration during animal evolution. Gaining insights into these evolutionarily conserved mechanisms will likely lead to achieving heart regeneration in non-regenerative mammals including humans. Springer Nature Singapore 2020-12-01 /pmc/articles/PMC7704876/ /pubmed/33258016 http://dx.doi.org/10.1186/s13619-020-00069-x Text en © The Author(s) 2020, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Opinion
Xiong, Jing-Wei
Evolutionary insights into heart regeneration
title Evolutionary insights into heart regeneration
title_full Evolutionary insights into heart regeneration
title_fullStr Evolutionary insights into heart regeneration
title_full_unstemmed Evolutionary insights into heart regeneration
title_short Evolutionary insights into heart regeneration
title_sort evolutionary insights into heart regeneration
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704876/
https://www.ncbi.nlm.nih.gov/pubmed/33258016
http://dx.doi.org/10.1186/s13619-020-00069-x
work_keys_str_mv AT xiongjingwei evolutionaryinsightsintoheartregeneration

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