(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model

Patients with familial type 17 of Parkinson’s disease (PARK17) manifest autosomal dominant pattern and late-onset parkinsonian syndromes. Heterozygous (D620N) mutation of vacuolar protein sorting 35 (VPS35) is genetic cause of PARK17. We prepared heterozygous VPS35(D620N/+) knockin mouse, which is a...

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Detalles Bibliográficos
Autores principales: Chiu, Ching-Chi, Weng, Yi-Hsin, Huang, Ying-Zu, Chen, Rou-Shayn, Liu, Yu-Chuan, Yeh, Tu-Hsueh, Lu, Chin-Song, Lin, Yan-Wei, Chen, Yu-Jie, Hsu, Chia-Chen, Chiu, Chi-Han, Wang, Yu-Ting, Chen, Wan-Shia, Liu, Shu-Yu, Wang, Hung-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705022/
https://www.ncbi.nlm.nih.gov/pubmed/33257649
http://dx.doi.org/10.1038/s41419-020-03228-9

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