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Research Note: A putative novel subtype of the avian hepatitis E virus of genotype 3, Jiangxi province, China
In recent years, the avian hepatitis E virus (HEV) has been widely spread in China, causing huge economic losses. Several studies have carried out detailed epidemiologic investigations of the avian HEV, but no data were from Jiangxi province. Since early April 2020, diseases similar to hepatic ruptu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705056/ https://www.ncbi.nlm.nih.gov/pubmed/33248582 http://dx.doi.org/10.1016/j.psj.2020.09.083 |
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author | Li, Haiqin Zhang, Fanfan Tan, Meifang Zeng, Yanbing Yang, Qun Tan, Jia Huang, Jiangnan Huang, Yu Kang, Zhaofeng |
author_facet | Li, Haiqin Zhang, Fanfan Tan, Meifang Zeng, Yanbing Yang, Qun Tan, Jia Huang, Jiangnan Huang, Yu Kang, Zhaofeng |
author_sort | Li, Haiqin |
collection | PubMed |
description | In recent years, the avian hepatitis E virus (HEV) has been widely spread in China, causing huge economic losses. Several studies have carried out detailed epidemiologic investigations of the avian HEV, but no data were from Jiangxi province. Since early April 2020, diseases similar to hepatic rupture hemorrhage syndrome caused by the avian HEV occurred in a Roman Brown layer farm in Jiangxi province, indicating this virus may also be epidemic there. To make this assumption clear, 20 liver samples were collected from the sick flock and then analyzed by detailed viral detection, which confirmed that the avian HEV should be responsible for the aforementioned disease (6 of 20). Then, the capsid gene of the virus was sequenced to show the molecular characteristics of the strain circulating in the aforementioned flock. Sequence comparison showed that it shared 80.7 to 94.7% identities with 12 published strains, while phylogenetic analysis confirmed that it belongs to a new subtype of genotype 3. Moreover, basing on a 242 bp fragment, the novel also shared high similarities to reference strains identified as genotypes before, revealing the genotype 3 maybe very popular in China and even can be divided into several subgroups. In conclusion, a novel avian HEV strain was identified in this study, which belongs to a new subtype of genotype 3. The analysis makes up for the molecular epidemiologic data of avian HEV and provides a basis for further understanding the spread of avian HEV in China. |
format | Online Article Text |
id | pubmed-7705056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-77050562020-12-08 Research Note: A putative novel subtype of the avian hepatitis E virus of genotype 3, Jiangxi province, China Li, Haiqin Zhang, Fanfan Tan, Meifang Zeng, Yanbing Yang, Qun Tan, Jia Huang, Jiangnan Huang, Yu Kang, Zhaofeng Poult Sci Immunology, Health and Disease In recent years, the avian hepatitis E virus (HEV) has been widely spread in China, causing huge economic losses. Several studies have carried out detailed epidemiologic investigations of the avian HEV, but no data were from Jiangxi province. Since early April 2020, diseases similar to hepatic rupture hemorrhage syndrome caused by the avian HEV occurred in a Roman Brown layer farm in Jiangxi province, indicating this virus may also be epidemic there. To make this assumption clear, 20 liver samples were collected from the sick flock and then analyzed by detailed viral detection, which confirmed that the avian HEV should be responsible for the aforementioned disease (6 of 20). Then, the capsid gene of the virus was sequenced to show the molecular characteristics of the strain circulating in the aforementioned flock. Sequence comparison showed that it shared 80.7 to 94.7% identities with 12 published strains, while phylogenetic analysis confirmed that it belongs to a new subtype of genotype 3. Moreover, basing on a 242 bp fragment, the novel also shared high similarities to reference strains identified as genotypes before, revealing the genotype 3 maybe very popular in China and even can be divided into several subgroups. In conclusion, a novel avian HEV strain was identified in this study, which belongs to a new subtype of genotype 3. The analysis makes up for the molecular epidemiologic data of avian HEV and provides a basis for further understanding the spread of avian HEV in China. Elsevier 2020-10-06 /pmc/articles/PMC7705056/ /pubmed/33248582 http://dx.doi.org/10.1016/j.psj.2020.09.083 Text en © 2020 Published by Elsevier Inc. on behalf of Poultry Science Association Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Immunology, Health and Disease Li, Haiqin Zhang, Fanfan Tan, Meifang Zeng, Yanbing Yang, Qun Tan, Jia Huang, Jiangnan Huang, Yu Kang, Zhaofeng Research Note: A putative novel subtype of the avian hepatitis E virus of genotype 3, Jiangxi province, China |
title | Research Note: A putative novel subtype of the avian hepatitis E virus of genotype 3, Jiangxi province, China |
title_full | Research Note: A putative novel subtype of the avian hepatitis E virus of genotype 3, Jiangxi province, China |
title_fullStr | Research Note: A putative novel subtype of the avian hepatitis E virus of genotype 3, Jiangxi province, China |
title_full_unstemmed | Research Note: A putative novel subtype of the avian hepatitis E virus of genotype 3, Jiangxi province, China |
title_short | Research Note: A putative novel subtype of the avian hepatitis E virus of genotype 3, Jiangxi province, China |
title_sort | research note: a putative novel subtype of the avian hepatitis e virus of genotype 3, jiangxi province, china |
topic | Immunology, Health and Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705056/ https://www.ncbi.nlm.nih.gov/pubmed/33248582 http://dx.doi.org/10.1016/j.psj.2020.09.083 |
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