Effect of probiotics, Bifidobacterium bifidum G9-1, on gastrointestinal symptoms in patients with type 2 diabetes mellitus: study protocol for open-label, single-arm, exploratory research trial (Big STAR study)

Metformin is associated with risks of gastrointestinal complications in patients with type 2 diabetes. In contrast, probiotic Bifidobacterium bifidum G9-1 (BBG9-1) could improve the symptoms of diarrhea caused by metformin in animal models. Thus, the primary outcome of this study will be the effect...

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Detalles Bibliográficos
Autores principales: Hashimoto, Yoshitaka, Nakajima, Hanako, Hata, Shinnosuke, Miyoshi, Tomoki, Hosomi, Yukako, Majima, Saori, Nakanishi, Naoko, Senmaru, Takafumi, Osaka, Takafumi, Okada, Hiroshi, Ushigome, Emi, Hamaguchi, Masahide, Asano, Mai, Yamazaki, Masahiro, Fukui, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2020
Materias:
Protocol Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705076/
https://www.ncbi.nlm.nih.gov/pubmed/33293761
http://dx.doi.org/10.3164/jcbn.20-100

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