Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland

Janus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are involved in the proliferation, differentiation, and survival of mammary gland epithelial cells. Dysregulation of JAK2-STAT5 activity invariably leads to mammary gland developmental defects and/or diseases, inc...

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Autores principales: Tian, Min, Qi, Yingao, Zhang, Xiaoli, Wu, Zhihui, Chen, Jiaming, Chen, Fang, Guan, Wutai, Zhang, Shihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705115/
https://www.ncbi.nlm.nih.gov/pubmed/33282878
http://dx.doi.org/10.3389/fcell.2020.604896
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author Tian, Min
Qi, Yingao
Zhang, Xiaoli
Wu, Zhihui
Chen, Jiaming
Chen, Fang
Guan, Wutai
Zhang, Shihai
author_facet Tian, Min
Qi, Yingao
Zhang, Xiaoli
Wu, Zhihui
Chen, Jiaming
Chen, Fang
Guan, Wutai
Zhang, Shihai
author_sort Tian, Min
collection PubMed
description Janus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are involved in the proliferation, differentiation, and survival of mammary gland epithelial cells. Dysregulation of JAK2-STAT5 activity invariably leads to mammary gland developmental defects and/or diseases, including breast cancer. Proper functioning of the JAK2-STAT5 signaling pathway relies on crosstalk with other signaling pathways (synergistically or antagonistically), which leads to normal biological performance. This review highlights recent progress regarding the critical components of the JAK2-STAT5 pathway and its crosstalk with G-protein coupled receptor (GPCR) signaling, PI3K-Akt signaling, growth factors, inflammatory cytokines, hormone receptors, and cell adhesion.
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spelling pubmed-77051152020-12-03 Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland Tian, Min Qi, Yingao Zhang, Xiaoli Wu, Zhihui Chen, Jiaming Chen, Fang Guan, Wutai Zhang, Shihai Front Cell Dev Biol Cell and Developmental Biology Janus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are involved in the proliferation, differentiation, and survival of mammary gland epithelial cells. Dysregulation of JAK2-STAT5 activity invariably leads to mammary gland developmental defects and/or diseases, including breast cancer. Proper functioning of the JAK2-STAT5 signaling pathway relies on crosstalk with other signaling pathways (synergistically or antagonistically), which leads to normal biological performance. This review highlights recent progress regarding the critical components of the JAK2-STAT5 pathway and its crosstalk with G-protein coupled receptor (GPCR) signaling, PI3K-Akt signaling, growth factors, inflammatory cytokines, hormone receptors, and cell adhesion. Frontiers Media S.A. 2020-11-17 /pmc/articles/PMC7705115/ /pubmed/33282878 http://dx.doi.org/10.3389/fcell.2020.604896 Text en Copyright © 2020 Tian, Qi, Zhang, Wu, Chen, Chen, Guan and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Tian, Min
Qi, Yingao
Zhang, Xiaoli
Wu, Zhihui
Chen, Jiaming
Chen, Fang
Guan, Wutai
Zhang, Shihai
Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_full Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_fullStr Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_full_unstemmed Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_short Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
title_sort regulation of the jak2-stat5 pathway by signaling molecules in the mammary gland
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705115/
https://www.ncbi.nlm.nih.gov/pubmed/33282878
http://dx.doi.org/10.3389/fcell.2020.604896
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