Cargando…

The Protective Role of the Carbohydrate Response Element Binding Protein in the Liver: The Metabolite Perspective

The Carbohydrate response element binding protein, ChREBP encoded by the MLXIPL gene, is a transcription factor that is expressed at high levels in the liver and has a prominent function during consumption of high-carbohydrate diets. ChREBP is activated by raised cellular levels of phosphate ester i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Agius, Loranne, Chachra, Shruti S., Ford, Brian E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705168/ https://www.ncbi.nlm.nih.gov/pubmed/33281747 http://dx.doi.org/10.3389/fendo.2020.594041

Ejemplares similares

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
por: Agius, Loranne, et al.
Publicado: (2020)

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
por: Moonira, Tabassum, et al.
Publicado: (2020)

The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases
por: Iizuka, Katsumi
Publicado: (2021)

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326
por: Ford, Brian E., et al.
Publicado: (2023)

Targeting Hepatic Glucokinase in Type 2 Diabetes: Weighing the Benefits and Risks
por: Agius, Loranne
Publicado: (2009)

Comment on: Stefanovski et al. Estimating Hepatic Glucokinase Activity Using a Simple Model of Lactate Kinetics. Diabetes Care 2012;35:1015–1020
por: Agius, Loranne
Publicado: (2012)

The Role of Carbohydrate Response Element Binding Protein in Intestinal and Hepatic Fructose Metabolism
por: Iizuka, Katsumi
Publicado: (2017)

Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance
por: Lei, Yu, et al.
Publicado: (2019)

Insulin-Like Growth Factor Binding Proteins: A Structural Perspective
por: Forbes, Briony E., et al.
Publicado: (2012)

Thyroid Hormones, Thyromimetics and Their Metabolites in the Treatment of Liver Disease
por: Kowalik, Marta A., et al.
Publicado: (2018)

A Slow-Digesting Carbohydrate Diet during Rat Pregnancy Protects Offspring from Non-Alcoholic Fatty Liver Disease Risk through the Modulation of the Carbohydrate-Response Element and Sterol Regulatory Element Binding Proteins
por: Salto, Rafael, et al.
Publicado: (2019)

Editorial: Current Perspectives on Insulin-Like Growth Factor Binding Protein (IGFBP) Research
por: Hoeflich, Andreas, et al.
Publicado: (2018)

Androgen dysfunction in non-alcoholic fatty liver disease: Role of sex hormone binding globulin
por: Song, Myeong Jun, et al.
Publicado: (2022)

The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis
por: Oguro, Hideyuki
Publicado: (2019)

Roles of Gut Microbial Metabolites in Diabetic Kidney Disease
por: Fang, Qing, et al.
Publicado: (2021)

Roles of gut microbiota and metabolites in overweight and obesity of children
por: Zhang, Shengan, et al.
Publicado: (2022)

IGF-Binding Proteins in Type-1 Diabetes Are More Severely Altered in the Presence of Complications
por: Sharma, Ashok, et al.
Publicado: (2016)

ERα down‐regulates carbohydrate responsive element binding protein and decreases aerobic glycolysis in liver cancer cells
por: Lu, Ying, et al.
Publicado: (2021)

Glucagon-like peptide-2 protects the gastric mucosa via regulating blood flow and metabolites
por: Zhang, Jing, et al.
Publicado: (2022)

The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility
por: Sillam-Dussès, David, et al.
Publicado: (2016)

Association between liver-type fatty acid-binding protein and hyperuricemia before and after laparoscopic sleeve gastrectomy
por: You, Hui, et al.
Publicado: (2022)

The Role of Vitamin D Binding Protein, Total and Free 25-Hydroxyvitamin D in Diabetes
por: Jorde, Rolf
Publicado: (2019)

Role of sphingolipid metabolites in the homeostasis of steroid hormones and the maintenance of testicular functions
por: Wang, Defan, et al.
Publicado: (2023)

Investigating causal associations among gut microbiota, metabolites, and liver diseases: a Mendelian randomization study
por: Zhang, Lilong, et al.
Publicado: (2023)

Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis
por: Arden, Catherine, et al.
Publicado: (2011)

Carbohydrate Loading Followed by High Carbohydrate Intake During Prolonged Physical Exercise and Its Impact on Glucose Control in Individuals With Diabetes Type 1—An Exploratory Study
por: Mattsson, Stig, et al.
Publicado: (2019)

Editorial: The role of the IGF axis in tumorigenesis and cancer treatment: From genes to metabolites
por: Mengzhe, Guo, et al.
Publicado: (2023)

The role of GnRH metabolite, GnRH-(1-5), in endometrial cancer
por: Cho-Clark, Madelaine J., et al.
Publicado: (2023)

Role of carbohydrate response element-binding protein (ChREBP) in generating an aerobic metabolic phenotype and in breast cancer progression
por: Airley, R E, et al.
Publicado: (2014)

Correction to ‘The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility’
por: Sillam-Dussès, David, et al.
Publicado: (2016)

MicroRNA, Proteins, and Metabolites as Novel Biomarkers for Prediabetes, Diabetes, and Related Complications
por: Vaishya, Suniti, et al.
Publicado: (2018)

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
por: Cullen, Kirsty S., et al.
Publicado: (2011)

The Potential Roles of Very Low Calorie, Very Low Calorie Ketogenic Diets and Very Low Carbohydrate Diets on the Gut Microbiota Composition
por: Rondanelli, Mariangela, et al.
Publicado: (2021)

Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A
por: Beattie, James, et al.
Publicado: (2018)

Physiological Role and Use of Thyroid Hormone Metabolites - Potential Utility in COVID-19 Patients
por: Fröhlich, Eleonore, et al.
Publicado: (2021)

Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non-alcoholic fatty liver disease
por: Cai, Can, et al.
Publicado: (2018)

Corrigendum: The Potential Roles of Very Low Calorie, Very Low Calorie Ketogenic Diets and Very Low Carbohydrate Diets on the Gut Microbiota Composition
por: Rondanelli, Mariangela, et al.
Publicado: (2021)

Integration of Proteomics and Metabolomics Revealed Metabolite–Protein Networks in ACTH-Secreting Pituitary Adenoma
por: Feng, Jie, et al.
Publicado: (2018)

Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation
por: Duncan, Elaine M., et al.
Publicado: (2023)

Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge
por: Karras, Spyridon N., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dkenqpp7c8583tsktsekmgv506