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The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment

BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is common in active acromegaly and negatively influences quality of life, morbidity, and mortality. This prospective study with 3 predetermined timepoints and a standardized treatment protocol investigates changes in sleep parameters during the fir...

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Autores principales: Wolters, Thalijn L C, Roerink, Sean H P P, Drenthen, Linda C A, van Haren-Willems, Jolanda H G M, Wagenmakers, Margaretha A E M, Smit, Johannes W A, Hermus, Adrianus R M M, Netea-Maier, Romana T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705224/
https://www.ncbi.nlm.nih.gov/pubmed/31612224
http://dx.doi.org/10.1210/clinem/dgz050
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author Wolters, Thalijn L C
Roerink, Sean H P P
Drenthen, Linda C A
van Haren-Willems, Jolanda H G M
Wagenmakers, Margaretha A E M
Smit, Johannes W A
Hermus, Adrianus R M M
Netea-Maier, Romana T
author_facet Wolters, Thalijn L C
Roerink, Sean H P P
Drenthen, Linda C A
van Haren-Willems, Jolanda H G M
Wagenmakers, Margaretha A E M
Smit, Johannes W A
Hermus, Adrianus R M M
Netea-Maier, Romana T
author_sort Wolters, Thalijn L C
collection PubMed
description BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is common in active acromegaly and negatively influences quality of life, morbidity, and mortality. This prospective study with 3 predetermined timepoints and a standardized treatment protocol investigates changes in sleep parameters during the first 2.5 years of acromegaly treatment. METHODS: Before initiation of acromegaly treatment (medical pretreatment followed by surgery), polysomnography (PSG) was performed in 27 consecutive patients with treatment-naive acromegaly. PSG was repeated after 1 year (N = 24) and 2.5 years (N = 23), and anthropometric and biochemical parameters were obtained. RESULTS: At baseline, 74.1% of the patients was diagnosed with OSAS. The respiratory disturbance index (RDI; P = 0.001), oxygen desaturation index (ODI; P = 0.001), lowest oxygen saturation (LSaO(2); P = 0.007) and the Epworth Sleepiness Scale (ESS; P < 0.001) improved significantly during treatment, with the greatest improvement in the first year. After 2.5 years of treatment, all patients had controlled acromegaly. Of the 16 patients with repeated PSG and OSAS at baseline, 11 (68.8%) were cured of OSAS. Changes in RDI, ODI, LSaO(2), and ESS correlated with insulin-like growth factor 1 levels. CONCLUSION: OSAS has a high prevalence in active acromegaly. There is a substantial decrease in prevalence and severity of OSAS following acromegaly treatment, with the largest improvement during the first year. Most patients recover from OSAS following surgical or biochemical control of the acromegaly. Therefore, a PSG is advised after diagnosis of acromegaly. When OSAS is present, it should be treated and PSG should be repeated during acromegaly treatment.
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spelling pubmed-77052242020-12-07 The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment Wolters, Thalijn L C Roerink, Sean H P P Drenthen, Linda C A van Haren-Willems, Jolanda H G M Wagenmakers, Margaretha A E M Smit, Johannes W A Hermus, Adrianus R M M Netea-Maier, Romana T J Clin Endocrinol Metab Clinical Research Articles BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is common in active acromegaly and negatively influences quality of life, morbidity, and mortality. This prospective study with 3 predetermined timepoints and a standardized treatment protocol investigates changes in sleep parameters during the first 2.5 years of acromegaly treatment. METHODS: Before initiation of acromegaly treatment (medical pretreatment followed by surgery), polysomnography (PSG) was performed in 27 consecutive patients with treatment-naive acromegaly. PSG was repeated after 1 year (N = 24) and 2.5 years (N = 23), and anthropometric and biochemical parameters were obtained. RESULTS: At baseline, 74.1% of the patients was diagnosed with OSAS. The respiratory disturbance index (RDI; P = 0.001), oxygen desaturation index (ODI; P = 0.001), lowest oxygen saturation (LSaO(2); P = 0.007) and the Epworth Sleepiness Scale (ESS; P < 0.001) improved significantly during treatment, with the greatest improvement in the first year. After 2.5 years of treatment, all patients had controlled acromegaly. Of the 16 patients with repeated PSG and OSAS at baseline, 11 (68.8%) were cured of OSAS. Changes in RDI, ODI, LSaO(2), and ESS correlated with insulin-like growth factor 1 levels. CONCLUSION: OSAS has a high prevalence in active acromegaly. There is a substantial decrease in prevalence and severity of OSAS following acromegaly treatment, with the largest improvement during the first year. Most patients recover from OSAS following surgical or biochemical control of the acromegaly. Therefore, a PSG is advised after diagnosis of acromegaly. When OSAS is present, it should be treated and PSG should be repeated during acromegaly treatment. Oxford University Press 2019-10-15 /pmc/articles/PMC7705224/ /pubmed/31612224 http://dx.doi.org/10.1210/clinem/dgz050 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Articles
Wolters, Thalijn L C
Roerink, Sean H P P
Drenthen, Linda C A
van Haren-Willems, Jolanda H G M
Wagenmakers, Margaretha A E M
Smit, Johannes W A
Hermus, Adrianus R M M
Netea-Maier, Romana T
The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment
title The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment
title_full The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment
title_fullStr The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment
title_full_unstemmed The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment
title_short The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment
title_sort course of obstructive sleep apnea syndrome in patients with acromegaly during treatment
topic Clinical Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705224/
https://www.ncbi.nlm.nih.gov/pubmed/31612224
http://dx.doi.org/10.1210/clinem/dgz050
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