Cargando…

Identification of Potential Key Agents for Targeting RNA-Dependent RNA Polymerase of SARS-CoV-2 by Integrated Analysis and Virtual Drug Screening

BACKGROUND: RNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for the SARS-CoV-2 replication process and catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA, often recognized as good targets for antiviral drugs. MATERIALS AND METHODS: A systematic sc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ao, Shuang, Han, Dan, Sun, Lei, Wu, Yanhong, Liu, Shuang, Huang, Yaojiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705243/ https://www.ncbi.nlm.nih.gov/pubmed/33281876 http://dx.doi.org/10.3389/fgene.2020.581668

Ejemplares similares

Origin and Evolution of RNA-Dependent RNA Polymerase
por: de Farias, Savio T., et al.
Publicado: (2017)

Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation
por: Hu, Xiaofeng, et al.
Publicado: (2019)

RNA Polymerase III, Ageing and Longevity
por: Kulaberoglu, Yavuz, et al.
Publicado: (2021)

Identification of FDA-approved drugs against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) through computational virtual screening
por: Jade, Dhananjay, et al.
Publicado: (2022)

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein
por: Maida, Yoshiko, et al.
Publicado: (2018)

The Novel Key Genes of Non-obstructive Azoospermia Affect Spermatogenesis: Transcriptomic Analysis Based on RNA-Seq and scRNA-Seq Data
por: He, Haihong, et al.
Publicado: (2021)

Corrigendum: RNA Polymerase III, Ageing and Longevity
por: Kulaberoglu, Yavuz, et al.
Publicado: (2021)

Deciphering inhibitory mechanism of coronavirus replication through host miRNAs-RNA-dependent RNA polymerase interactome
por: Morenikeji, Olanrewaju B., et al.
Publicado: (2022)

Discovery of Potential Inhibitors for RNA-Dependent RNA Polymerase of Norovirus: Virtual Screening, and Molecular Dynamics
por: Ebenezer, Oluwakemi, et al.
Publicado: (2020)

SARS-CoV-2 RNA-dependent RNA polymerase as a target for high-throughput drug screening
por: Wu, Jiahui, et al.
Publicado: (2023)

Identification of Key lncRNA–mRNA Pairs and Functional lncRNAs in Breast Cancer by Integrative Analysis of TCGA Data
por: Li, Zhe, et al.
Publicado: (2021)

Identification of miRNA-Mediated Subpathways as Prostate Cancer Biomarkers Based on Topological Inference in a Machine Learning Process Using Integrated Gene and miRNA Expression Data
por: Ning, Ziyu, et al.
Publicado: (2021)

Structure based virtual screening of inhibitors for binding at the allosteric site of HCV RNA dependent RNA polymerase
por: Revikumar, Amjesh, et al.
Publicado: (2012)

Discovering new potential inhibitors to SARS-CoV-2 RNA dependent RNA polymerase (RdRp) using high throughput virtual screening and molecular dynamics simulations
por: Brunt, Dylan, et al.
Publicado: (2022)

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
por: Yin, Wanchao, et al.
Publicado: (2020)

Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
por: Aranda, Juan, et al.
Publicado: (2022)

Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase
por: Zandi, Keivan, et al.
Publicado: (2021)

In silico prediction of the animal susceptibility and virtual screening of natural compounds against SARS-CoV-2: Molecular dynamics simulation based analysis
por: Garg, Priyanka, et al.
Publicado: (2022)

Identification of Potential Key Genes for Pathogenesis and Prognosis in Prostate Cancer by Integrated Analysis of Gene Expression Profiles and the Cancer Genome Atlas
por: Liu, Shuang, et al.
Publicado: (2020)

Identification of the Key Factors Related to Bladder Cancer by lncRNA-miRNA-mRNA Three-Layer Network
por: Wang, Xiaxia, et al.
Publicado: (2020)

Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP
por: Naydenova, Katerina, et al.
Publicado: (2021)

Inhibition of the RNA-dependent RNA Polymerase of the SARS-CoV-2 by Short Peptide Inhibitors
por: Pant, Suyash, et al.
Publicado: (2021)

Single molecule activity assay for SARS-CoV-2 RNA dependent RNA polymerase
por: Chung, SangYoon, et al.
Publicado: (2022)

Electron Density Analysis of SARS-CoV-2 RNA-Dependent RNA Polymerase Complexes
por: Palko, Nadezhda, et al.
Publicado: (2021)

Expression pattern and clinical value of Key RNA methylation modification regulators in ischemic stroke
por: Zhang, Xinyue, et al.
Publicado: (2022)

Pharmacophore screening to identify natural origin compounds to target RNA-dependent RNA polymerase (RdRp) of SARS-CoV2
por: Mishra, Avinash, et al.
Publicado: (2022)

Integrated Analysis of circRNA-miRNA-mRNA ceRNA Network in Cardiac Hypertrophy
por: Chen, Yang-Hao, et al.
Publicado: (2022)

Identification of LINC00173 in Myasthenia Gravis by Integration Analysis of Aberrantly Methylated- Differentially Expressed Genes and ceRNA Networks
por: Xu, Si, et al.
Publicado: (2021)

The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation
por: Jiang, Shengyang, et al.
Publicado: (2019)

Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis
por: Liu, Xue, et al.
Publicado: (2020)

Comprehensive Bioinformatics Analysis to Reveal Key RNA Targets and Hub Competitive Endogenous RNA Network of Keratoconus
por: Ouyang, Shuai, et al.
Publicado: (2022)

Dynamic properties of SARS-CoV and SARS-CoV-2 RNA-dependent RNA polymerases studied by molecular dynamics simulations
por: Itoh, Satoru G., et al.
Publicado: (2021)

Data-Driven and Machine-Learning Methods to Project Coronavirus Disease 2019 Pandemic Trend in Eastern Mediterranean
por: Huang, Wenbo, et al.
Publicado: (2021)

Identification of Potent Zika Virus NS5 RNA-Dependent RNA Polymerase Inhibitors Combining Virtual Screening and Biological Assays
por: Chen, Ying, et al.
Publicado: (2023)

Screening of SARS-CoV-2 antivirals through a cell-based RNA-dependent RNA polymerase (RdRp) reporter assay
por: Uppal, Timsy, et al.
Publicado: (2022)

Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2
por: Pokhrel, Rudramani, et al.
Publicado: (2020)

Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2
por: Arba, Muhammad, et al.
Publicado: (2021)

Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase
por: Li, Quanjie, et al.
Publicado: (2021)

The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
por: Jin, Zhenming, et al.
Publicado: (2021)

A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase
por: Khan, Suliman, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7ufhmognn47ph6if564f3hmqe4