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Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control
PURPOSE OF THE REVIEW: This review aims to critically assess current knowledge about the epidemiology, diagnosis, and management of Fasciola infection in humans. RECENT FINDINGS: Fascioliasis is an emerging neglected zoonotic infection affecting the health and wellbeing of human populations. The bur...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705270/ https://www.ncbi.nlm.nih.gov/pubmed/33273878 http://dx.doi.org/10.2147/RRTM.S237461 |
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author | Caravedo, Maria Alejandra Cabada, Miguel Mauricio |
author_facet | Caravedo, Maria Alejandra Cabada, Miguel Mauricio |
author_sort | Caravedo, Maria Alejandra |
collection | PubMed |
description | PURPOSE OF THE REVIEW: This review aims to critically assess current knowledge about the epidemiology, diagnosis, and management of Fasciola infection in humans. RECENT FINDINGS: Fascioliasis is an emerging neglected zoonotic infection affecting the health and wellbeing of human populations. The burden of infection is unclear, and studies have shown the geographic expansion of fascioliasis in human and livestock likely related to climate change. The infection can be asymptomatic or present in acute or chronic forms. Regardless of the presentation, fascioliasis can be associated with long-term complications such as anemia and malnutrition. Early in the infection, antibody testing is the only tool available for diagnosis confirmation. In the chronic forms serology and stool microscopy are helpful. Other tests such as antigen detection and PCR-based methods including isothermal tests have shown promising results. Triclabendazole is the only drug available to treat Fasciola infection. However, reports of resistant infections in livestock and human threaten the clinical care and control of the infection in endemic areas. SUMMARY: Fascioliasis is an emerging infection around the world with an uncertain burden. Lack of standardization of diagnostic testing and treatment alternatives hinder treatment and control of the infection. |
format | Online Article Text |
id | pubmed-7705270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-77052702020-12-02 Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control Caravedo, Maria Alejandra Cabada, Miguel Mauricio Res Rep Trop Med Review PURPOSE OF THE REVIEW: This review aims to critically assess current knowledge about the epidemiology, diagnosis, and management of Fasciola infection in humans. RECENT FINDINGS: Fascioliasis is an emerging neglected zoonotic infection affecting the health and wellbeing of human populations. The burden of infection is unclear, and studies have shown the geographic expansion of fascioliasis in human and livestock likely related to climate change. The infection can be asymptomatic or present in acute or chronic forms. Regardless of the presentation, fascioliasis can be associated with long-term complications such as anemia and malnutrition. Early in the infection, antibody testing is the only tool available for diagnosis confirmation. In the chronic forms serology and stool microscopy are helpful. Other tests such as antigen detection and PCR-based methods including isothermal tests have shown promising results. Triclabendazole is the only drug available to treat Fasciola infection. However, reports of resistant infections in livestock and human threaten the clinical care and control of the infection in endemic areas. SUMMARY: Fascioliasis is an emerging infection around the world with an uncertain burden. Lack of standardization of diagnostic testing and treatment alternatives hinder treatment and control of the infection. Dove 2020-11-26 /pmc/articles/PMC7705270/ /pubmed/33273878 http://dx.doi.org/10.2147/RRTM.S237461 Text en © 2020 Caravedo and Cabada. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Caravedo, Maria Alejandra Cabada, Miguel Mauricio Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control |
title | Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control |
title_full | Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control |
title_fullStr | Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control |
title_full_unstemmed | Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control |
title_short | Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control |
title_sort | human fascioliasis: current epidemiological status and strategies for diagnosis, treatment, and control |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705270/ https://www.ncbi.nlm.nih.gov/pubmed/33273878 http://dx.doi.org/10.2147/RRTM.S237461 |
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