Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2. On the basis of our previously identified humanized cro...

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Detalles Bibliográficos
Autores principales: Yao, Hangping, Sun, Yao, Deng, Yong-Qiang, Wang, Nan, Tan, Yongcong, Zhang, Na-Na, Li, Xiao-Feng, Kong, Chao, Xu, Yan-Peng, Chen, Qi, Cao, Tian-Shu, Zhao, Hui, Yan, Xintian, Cao, Lei, Lv, Zhe, Zhu, Dandan, Feng, Rui, Wu, Nanping, Zhang, Wenhai, Hu, Yuhao, Chen, Keda, Zhang, Rong-Rong, Lv, Qingyu, Sun, Shihui, Zhou, Yunhua, Yan, Run, Yang, Guan, Sun, Xinglu, Liu, Chanjuan, Lu, Xiangyun, Cheng, Linfang, Qiu, Hongying, Huang, Xing-Yao, Weng, Tianhao, Shi, Danrong, Jiang, Weidong, Shao, Junbin, Wang, Lei, Zhang, Jie, Jiang, Tao, Lang, Guojun, Qin, Cheng-Feng, Li, Lanjuan, Wang, Xiangxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705443/
https://www.ncbi.nlm.nih.gov/pubmed/33262452
http://dx.doi.org/10.1038/s41422-020-00444-y

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