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New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair

Tooth enamel, a highly mineralized tissue covering the outermost area of teeth, is always damaged by dental caries or trauma. Tooth enamel rarely repairs or renews itself, due to the loss of ameloblasts and dental epithelial stem cells (DESCs) once the tooth erupts. Unlike human teeth, mouse incisor...

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Autores principales: Gan, Lu, Liu, Ying, Cui, Di-Xin, Pan, Yue, Wan, Mian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705464/
https://www.ncbi.nlm.nih.gov/pubmed/33312401
http://dx.doi.org/10.4252/wjsc.v12.i11.1327
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author Gan, Lu
Liu, Ying
Cui, Di-Xin
Pan, Yue
Wan, Mian
author_facet Gan, Lu
Liu, Ying
Cui, Di-Xin
Pan, Yue
Wan, Mian
author_sort Gan, Lu
collection PubMed
description Tooth enamel, a highly mineralized tissue covering the outermost area of teeth, is always damaged by dental caries or trauma. Tooth enamel rarely repairs or renews itself, due to the loss of ameloblasts and dental epithelial stem cells (DESCs) once the tooth erupts. Unlike human teeth, mouse incisors grow continuously due to the presence of DESCs that generate enamel-producing ameloblasts and other supporting dental epithelial lineages. The ready accessibility of mouse DESCs and wide availability of related transgenic mouse lines make mouse incisors an excellent model to examine the identity and heterogeneity of dental epithelial stem/progenitor cells; explore the regulatory mechanisms underlying enamel formation; and help answer the open question regarding the therapeutic development of enamel engineering. In the present review, we update the current understanding about the identification of DESCs in mouse incisors and summarize the regulatory mechanisms of enamel formation driven by DESCs. The roles of DESCs during homeostasis and repair are also discussed, which should improve our knowledge regarding enamel tissue engineering.
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spelling pubmed-77054642020-12-10 New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair Gan, Lu Liu, Ying Cui, Di-Xin Pan, Yue Wan, Mian World J Stem Cells Review Tooth enamel, a highly mineralized tissue covering the outermost area of teeth, is always damaged by dental caries or trauma. Tooth enamel rarely repairs or renews itself, due to the loss of ameloblasts and dental epithelial stem cells (DESCs) once the tooth erupts. Unlike human teeth, mouse incisors grow continuously due to the presence of DESCs that generate enamel-producing ameloblasts and other supporting dental epithelial lineages. The ready accessibility of mouse DESCs and wide availability of related transgenic mouse lines make mouse incisors an excellent model to examine the identity and heterogeneity of dental epithelial stem/progenitor cells; explore the regulatory mechanisms underlying enamel formation; and help answer the open question regarding the therapeutic development of enamel engineering. In the present review, we update the current understanding about the identification of DESCs in mouse incisors and summarize the regulatory mechanisms of enamel formation driven by DESCs. The roles of DESCs during homeostasis and repair are also discussed, which should improve our knowledge regarding enamel tissue engineering. Baishideng Publishing Group Inc 2020-11-26 2020-11-26 /pmc/articles/PMC7705464/ /pubmed/33312401 http://dx.doi.org/10.4252/wjsc.v12.i11.1327 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Gan, Lu
Liu, Ying
Cui, Di-Xin
Pan, Yue
Wan, Mian
New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair
title New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair
title_full New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair
title_fullStr New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair
title_full_unstemmed New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair
title_short New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair
title_sort new insight into dental epithelial stem cells: identification, regulation, and function in tooth homeostasis and repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705464/
https://www.ncbi.nlm.nih.gov/pubmed/33312401
http://dx.doi.org/10.4252/wjsc.v12.i11.1327
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