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New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair
Tooth enamel, a highly mineralized tissue covering the outermost area of teeth, is always damaged by dental caries or trauma. Tooth enamel rarely repairs or renews itself, due to the loss of ameloblasts and dental epithelial stem cells (DESCs) once the tooth erupts. Unlike human teeth, mouse incisor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705464/ https://www.ncbi.nlm.nih.gov/pubmed/33312401 http://dx.doi.org/10.4252/wjsc.v12.i11.1327 |
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author | Gan, Lu Liu, Ying Cui, Di-Xin Pan, Yue Wan, Mian |
author_facet | Gan, Lu Liu, Ying Cui, Di-Xin Pan, Yue Wan, Mian |
author_sort | Gan, Lu |
collection | PubMed |
description | Tooth enamel, a highly mineralized tissue covering the outermost area of teeth, is always damaged by dental caries or trauma. Tooth enamel rarely repairs or renews itself, due to the loss of ameloblasts and dental epithelial stem cells (DESCs) once the tooth erupts. Unlike human teeth, mouse incisors grow continuously due to the presence of DESCs that generate enamel-producing ameloblasts and other supporting dental epithelial lineages. The ready accessibility of mouse DESCs and wide availability of related transgenic mouse lines make mouse incisors an excellent model to examine the identity and heterogeneity of dental epithelial stem/progenitor cells; explore the regulatory mechanisms underlying enamel formation; and help answer the open question regarding the therapeutic development of enamel engineering. In the present review, we update the current understanding about the identification of DESCs in mouse incisors and summarize the regulatory mechanisms of enamel formation driven by DESCs. The roles of DESCs during homeostasis and repair are also discussed, which should improve our knowledge regarding enamel tissue engineering. |
format | Online Article Text |
id | pubmed-7705464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-77054642020-12-10 New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair Gan, Lu Liu, Ying Cui, Di-Xin Pan, Yue Wan, Mian World J Stem Cells Review Tooth enamel, a highly mineralized tissue covering the outermost area of teeth, is always damaged by dental caries or trauma. Tooth enamel rarely repairs or renews itself, due to the loss of ameloblasts and dental epithelial stem cells (DESCs) once the tooth erupts. Unlike human teeth, mouse incisors grow continuously due to the presence of DESCs that generate enamel-producing ameloblasts and other supporting dental epithelial lineages. The ready accessibility of mouse DESCs and wide availability of related transgenic mouse lines make mouse incisors an excellent model to examine the identity and heterogeneity of dental epithelial stem/progenitor cells; explore the regulatory mechanisms underlying enamel formation; and help answer the open question regarding the therapeutic development of enamel engineering. In the present review, we update the current understanding about the identification of DESCs in mouse incisors and summarize the regulatory mechanisms of enamel formation driven by DESCs. The roles of DESCs during homeostasis and repair are also discussed, which should improve our knowledge regarding enamel tissue engineering. Baishideng Publishing Group Inc 2020-11-26 2020-11-26 /pmc/articles/PMC7705464/ /pubmed/33312401 http://dx.doi.org/10.4252/wjsc.v12.i11.1327 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Gan, Lu Liu, Ying Cui, Di-Xin Pan, Yue Wan, Mian New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair |
title | New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair |
title_full | New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair |
title_fullStr | New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair |
title_full_unstemmed | New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair |
title_short | New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair |
title_sort | new insight into dental epithelial stem cells: identification, regulation, and function in tooth homeostasis and repair |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705464/ https://www.ncbi.nlm.nih.gov/pubmed/33312401 http://dx.doi.org/10.4252/wjsc.v12.i11.1327 |
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