Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells

BACKGROUND: Cellular metabolism regulates stemness in health and disease.  A reduced redox state is essential for self-renewal of normal and cancer stem cells (CSCs). However, while stem cells rely on glycolysis, different CSCs, including pancreatic CSCs, favor mitochondrial metabolism as their domi...

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Detalles Bibliográficos
Autores principales: Jagust, Petra, Alcalá, Sonia, Sainz Jr, Bruno, Heeschen, Christopher, Sancho, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705467/
https://www.ncbi.nlm.nih.gov/pubmed/33312407
http://dx.doi.org/10.4252/wjsc.v12.i11.1410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705467/
https://www.ncbi.nlm.nih.gov/pubmed/33312407
http://dx.doi.org/10.4252/wjsc.v12.i11.1410

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