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Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes

INTRODUCTION: Pancreatic duodenum homeobox 1 (Pdx1) expression is crucial for pancreatic organogenesis and is a key regulator of insulin gene expression. Hairy and enhancer of split 1 (Hes1) controls tissue morphogenesis by maintaining undifferentiated cells. Hes1 encodes a basic helix loop helix (b...

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Autores principales:	Nagaya, Masaki, Hasegawa, Koki, Watanabe, Masahito, Nakano, Kazuaki, Okamoto, Kazutoshi, Yamada, Takeshi, Uchikura, Ayuko, Osafune, Kenji, Yokota, Harumasa, Nagaoka, Taiji, Matsunari, Hitomi, Umeyama, Kazuhiro, Kobayashi, Eiji, Nakauchi, Hiromitsu, Nagashima, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Pathophysiology/Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705540/ https://www.ncbi.nlm.nih.gov/pubmed/33257422 http://dx.doi.org/10.1136/bmjdrc-2020-001792

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