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Uveal melanoma-associated cancers revisited
BACKGROUND: Uveal melanoma (UM) is the most common primary ocular malignancy of adults. A small group of patients was found to express familial predisposition. Moreover, it may be preceded or followed by other malignancies elsewhere in the body. We aim to compare the incidence of UM and other associ...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705551/ https://www.ncbi.nlm.nih.gov/pubmed/33257317 http://dx.doi.org/10.1136/esmoopen-2020-000990 |
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author | Alfaar, Ahmad Samir Saad, Anas Elzouki, Shiema Abdel-Rahman, Mohamed H Strauss, Olaf Rehak, Matus |
author_facet | Alfaar, Ahmad Samir Saad, Anas Elzouki, Shiema Abdel-Rahman, Mohamed H Strauss, Olaf Rehak, Matus |
author_sort | Alfaar, Ahmad Samir |
collection | PubMed |
description | BACKGROUND: Uveal melanoma (UM) is the most common primary ocular malignancy of adults. A small group of patients was found to express familial predisposition. Moreover, it may be preceded or followed by other malignancies elsewhere in the body. We aim to compare the incidence of UM and other associated cancers and study the factors that may influence each condition. PATIENTS AND METHODS: We have collected the data from the Surveillance, Epidemiology and End Results database of nine US cancer registries for UM patients between 1973 and 2015. We calculated the standardised incidence ratios for single primary UM, first primary and second primary UM, and compared the groups for multiple factors. RESULTS: A total of 4946 patients were included in the study; 3863 with single primary UM, 646 developed a second primary malignancy following UM, and 437 patients developed second primary UM following a previous primary malignancy. The risk of developing UM increased after leukaemia, melanoma of the skin and prostate. On the other side, the risk of developing melanoma of the skin, thyroid, renal and other eye and orbit malignancies has increased significantly after initial UM. This risk was more evident in the age group between 50 and 70 years old. Cancer-specific survival was significantly higher in UM associated with other malignancies group compared with single primary UM. CONCLUSION: Our study showed a different behaviour of the UM when associated with other tumours that exceed the known spectrum of hereditary UM. Further studies are required to dissect the genetic background of this behaviour. |
format | Online Article Text |
id | pubmed-7705551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-77055512020-12-09 Uveal melanoma-associated cancers revisited Alfaar, Ahmad Samir Saad, Anas Elzouki, Shiema Abdel-Rahman, Mohamed H Strauss, Olaf Rehak, Matus ESMO Open Original Research BACKGROUND: Uveal melanoma (UM) is the most common primary ocular malignancy of adults. A small group of patients was found to express familial predisposition. Moreover, it may be preceded or followed by other malignancies elsewhere in the body. We aim to compare the incidence of UM and other associated cancers and study the factors that may influence each condition. PATIENTS AND METHODS: We have collected the data from the Surveillance, Epidemiology and End Results database of nine US cancer registries for UM patients between 1973 and 2015. We calculated the standardised incidence ratios for single primary UM, first primary and second primary UM, and compared the groups for multiple factors. RESULTS: A total of 4946 patients were included in the study; 3863 with single primary UM, 646 developed a second primary malignancy following UM, and 437 patients developed second primary UM following a previous primary malignancy. The risk of developing UM increased after leukaemia, melanoma of the skin and prostate. On the other side, the risk of developing melanoma of the skin, thyroid, renal and other eye and orbit malignancies has increased significantly after initial UM. This risk was more evident in the age group between 50 and 70 years old. Cancer-specific survival was significantly higher in UM associated with other malignancies group compared with single primary UM. CONCLUSION: Our study showed a different behaviour of the UM when associated with other tumours that exceed the known spectrum of hereditary UM. Further studies are required to dissect the genetic background of this behaviour. BMJ Publishing Group 2020-11-30 /pmc/articles/PMC7705551/ /pubmed/33257317 http://dx.doi.org/10.1136/esmoopen-2020-000990 Text en © Author (s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, any changes made are indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Original Research Alfaar, Ahmad Samir Saad, Anas Elzouki, Shiema Abdel-Rahman, Mohamed H Strauss, Olaf Rehak, Matus Uveal melanoma-associated cancers revisited |
title | Uveal melanoma-associated cancers revisited |
title_full | Uveal melanoma-associated cancers revisited |
title_fullStr | Uveal melanoma-associated cancers revisited |
title_full_unstemmed | Uveal melanoma-associated cancers revisited |
title_short | Uveal melanoma-associated cancers revisited |
title_sort | uveal melanoma-associated cancers revisited |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705551/ https://www.ncbi.nlm.nih.gov/pubmed/33257317 http://dx.doi.org/10.1136/esmoopen-2020-000990 |
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